No correlation between A(-1438)G polymorphism in 5-HT2A receptor gene promoter and the density of frontal cortical 5-HT2A receptors in schizophrenia

被引：63
作者：
Kouzmenko, AP
Scaffidi, A
Pereira, AM
Hayes, WL
Copolov, DL
Dean, B
机构：
[1] Mental Hlth Res Inst Victoria, Div Mol Schizophrenia, Parkville, Vic, Australia
[2] Univ Melbourne, Dept Psychiat, Parkville, Vic 3052, Australia
[3] Univ Melbourne, Dept Pathol, Parkville, Vic 3052, Australia
来源：
HUMAN HEREDITY | 1999年 / 49卷 / 02期
关键词：
5HT2a receptor; polymorphism; promoter; human brain; schizophrenia;
D O I：
10.1159/000022853
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The A(-1438)G promoter polymorphism of the 5-hydroxytryptamine 2a receptor (5-HT2AR) gene and its influence on the cortical density of 5-HT2AR was studied using brain tissue donated at autopsy from 58 schizophrenic and 64 non-schizophrenic subjects. A linkage between genotypes for the A(-1438)G and a T102C polymorphic site identified in a previous study was observed. Our data suggest no association of the A(-1438)G polymorphism with schizophrenia and no effect of the promoter genotype upon 5-HT2AR densities in either the schizophrenic or non-schizophrenic groups.
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收藏
页码：103 / 105
页数：3
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