Aberrant methylation of the PTPRO gene in peripheral blood as a potential biomarker in esophageal squamous cell carcinoma patients

被引:35
作者
You, Yan-Jie [1 ,2 ,4 ]
Chen, Yu-Ping [5 ]
Zheng, Xiao-Xuan [1 ]
Meltzer, Stephen J. [6 ,7 ,8 ]
Zhang, Hao [1 ,2 ,3 ,4 ]
机构
[1] Shantou Univ, Coll Med, Canc Res Ctr, Shantou 515041, Peoples R China
[2] Shantou Univ, Coll Med, Canc Hosp, Dept Integrat Chinese & Western Med, Shantou 515041, Peoples R China
[3] Shantou Univ, Coll Med, Tumor Tissue Bank, Canc Hosp, Shantou 515041, Peoples R China
[4] Shantou Univ, Coll Med, Canc Hosp, Oncol Res Lab, Shantou 515041, Peoples R China
[5] Shantou Univ, Coll Med, Canc Hosp, Dept Surg, Shantou 515041, Peoples R China
[6] Johns Hopkins Univ, Sch Med, Dept Med, Div Gastroenterol, Baltimore, MD 21205 USA
[7] Johns Hopkins Univ, Sch Med, Dept Oncol, Div Gastroenterol, Baltimore, MD 21205 USA
[8] Johns Hopkins Univ, Sch Med, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD USA
基金
高等学校博士学科点专项科研基金; 中国国家自然科学基金;
关键词
PTPRO; DNA methylation; Epigenetics; Cancer surveillance and screening; PROTEIN-TYROSINE-PHOSPHATASE; RECEPTOR-TYPE-O; PROMOTER HYPERMETHYLATION; LUNG-CANCER; NASOPHARYNGEAL CARCINOMA; MOLECULAR-DETECTION; TUMOR-SUPPRESSOR; DNA; PLASMA; SERUM;
D O I
10.1016/j.canlet.2011.08.032
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Epigenetic inactivation of protein tyrosine phosphatase receptor-type 0 (PTPRO). a new member of the PTP family, has been described in several forms of cancer. We evaluated PTPRO promoter hypermethylation as a potential biomarker in esophageal squamous cell carcinoma (ESCC). This alteration was observed in 27 (75%) of 36 primary tumors and correlated significantly with depth of invasion (T-stage, P=0.013). Among matched peripheral blood samples from ESCC patients, 13 (36.1%) of 36 exhibited detectable methylated PTPRO in plasma, while 15(41.7%) of 36 had this abnormality in buffy coat. No methylated PTPRO was observed in normal peripheral blood samples from 10 healthy individuals. In addition, demethylation by 5-aza-dC treatment led to gene reactivation in PTPRO-methylated and silenced ESCC cell lines. To our knowledge, this is the first report of methylated PTPRO as a noninvasive tumor biomarker in peripheral blood. These findings suggest that hypermethylated PTPRO occurs frequently in ESCC. Further, detection in peripheral blood of ESCC patients suggests potential clinical application for noninvasive diagnosis and disease monitoring. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:138 / 144
页数:7
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