Activation of toll-like receptors by microbial lipoproteins: Role in host defense

被引：9

作者：

Modlin, RL

机构：

[1] Univ Calif Los Angeles, Sch Med, Div Dermatol, Dept Med, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Sch Med, Dept Microbiol & Immunol, Inst Mol Biol, Los Angeles, CA 90095 USA

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2001年 / 108卷 / 04期

关键词：

toll; innate immunity; tuberculosis; IL-12;

D O I：

10.1067/mai.2001.118299

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Conserved throughout evolution, mammalian toll-like receptors (TLRs) participate in innate immune response to microbial pathogens. The TLRs mediate activation by microbial ligands, resulting in cytokine activation as well as other host defense mechanisms. Activation of TLRs also can result in tissue injury including manifestations of septic shock and host cell apoptosis. In this manner, the activation of mammalian TLRs in the context of infectious disease can contribute to host defense and immunopathology.

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收藏

页码：S104 / S106

页数：3

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