Interface modified polylactic acid/starch/poly ε-caprolactone antibacterial nanocomposite blends for medical applications

被引：60

作者：

Davachi, Seyed Mohammad ^{[1
]}

Heidari, Behzad Shiroud ^{[2
]}

Hejazi, Iman ^{[2
]}

Seyfi, Javad ^{[3
]}

Oliaei, Erfan ^{[2
]}

Farzaneh, Arman ^{[2
]}

Rashedi, Hamid ^{[4
]}

机构：

[1] Islamic Azad Univ, Cent Tehran Branch, Fac Engn, Dept Chem Engn, POB 13185-768, Tehran, Iran

[2] ASNARKA PC, Appl Sci Nano Res Grp, Tehran 1619948753, Iran

[3] Islamic Azad Univ, Shahrood Branch, Dept Chem Engn, POB 36155-163, Shahrood, Iran

[4] Univ Tehran, Coll Engn, Sch Chem Engn, Dept Biotechnol, Tehran, Iran

来源：

CARBOHYDRATE POLYMERS | 2017年 / 155卷

关键词：

PLA; PCL; Starch; Interface modified blend; Antibacterial; Nano hydroxyapatite; L-LACTIDE/TRICLOSAN NANOPARTICLES; TERNARY BLENDS; L-LACTIDE; PLLA/TRICLOSAN/NANO-HYDROXYAPATITE; HYDROLYTIC DEGRADATION; RHEOLOGICAL PROPERTIES; CARBONATE TERPOLYMERS; INCLUSION COMPLEXES; STARCH; POLYCAPROLACTONE;

D O I：

10.1016/j.carbpol.2016.08.037

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

In this study, an optimized interface-modified ternary blend with antibacterial activity based on polylactic acid/starch/poly epsilon-caprolactone (PLASCL20), mixed with nano hydroxyapatite (nHA) via melt blending. This method results in a homogeneous nanocomposite blend in which the addition of 3% nHA improves the overall properties such as hydrolytic degradation, hydrophilicity, antibacterial activity and the drug release comparing to PLASCL20. Moreover, the simultaneous use of nHA and encapsulated triclosan (LATC30) compensated the negative effect of triclosan through increasing the possible cell attachment. According to the contact angle results, nHA was thermodynamically driven into the interface of PLA and PCL/Starch phases. The addition of 3% nHA showed a good adjustment between the hydrolytic degradation and the release profile, therefore, their electrospun microfibers demonstrated an improved fibroblast (L929) cell attachment. The aforementioned nanocomposite blend is a suitable antibacterial candidate for many medical applications with minimum side effects due to the controlled release of triclosan. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：336 / 344

页数：9

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