A phase 3 study comparing switching from tenofovir disoproxil fumarate (TDF) to tenofovir alafenamide (TAF) with continued TDF treatment in virologically-suppressed patients with chronic hepatitis B (CHB): final week 96 efficacy and safety results

被引：0

作者：

Lampertico, Pietro ^{[1
]}

Buti, Maria ^{[2
]}

Ramji, Alnoor ^{[3
]}

Fung, Scott ^{[4
]}

Ahn, Sang Hoon ^{[5
]}

Chuang, Wan-Long ^{[6
]}

Yoon, Seung Kew ^{[7
]}

Kao, Jia-Horng ^{[8
]}

Chen, Chi-Yi ^{[9
]}

Tam, Edward ^{[10
]}

Khalili, Mandana ^{[11
]}

Bae, Ho ^{[12
]}

Ma, Xiaoli ^{[13
]}

Tak, Won Young ^{[14
]}

Flaherty, John F. ^{[15
]}

Gaggar, Anuj ^{[15
]}

Suri, Vithika ^{[15
]}

Tan, Susanna ^{[15
]}

Liu, Yang ^{[15
]}

Wu, George ^{[15
]}

Subramanian, Mani ^{[15
]}

Hann, Hie-Won ^{[16
]}

Agarwal, Kosh ^{[17
]}

Lim, Young-Suk ^{[18
,19
]}

Chan, Henry ^{[19
,20
]}

机构：

[1] Univ Milan, Fdn IRCCS Ca Granda Osped Maggiore Policlin, Milan, Italy

[2] Hosp Gen Univ Valle Hebron & Ciberehd, Barcelona, Spain

[3] Univ British Columbia, Div Gastroenterol, Vancouver, BC, Canada

[4] Toronto Gen Hosp, Univ Hlth Network, Toronto Ctr Liver Dis, Toronto, ON, Canada

[5] Yonsei Univ, Inst Gastroenterol, Dept Internal Med, Coll Med, Seoul, South Korea

[6] Kaohsiung Med Univ Hosp, Hepatobiliary Div, Dept Internal Med, Kaohsiung, Taiwan

[7] Catholic Univ Korea, Dept Internal Med, Seoul, South Korea

[8] Natl Taiwan Univ Hosp, Div Gastroenterol & Hepatol, Taipei, Taiwan

[9] Chia Yi Christian Hosp, Chiayi, Taiwan

[10] LAIR Ctr, Vancouver, BC, Canada

[11] Univ Calif San Francisco, San Francisco, CA 94143 USA

[12] St Vincents Med Ctr, Los Angeles, CA USA

[13] Drexel Univ, Coll Med, Philadelphia, PA USA

[14] Kyungpook Natl Univ, Coll Med, Daegu, South Korea

[15] Gilead Sci Inc, 353 Lakeside Dr, Foster City, CA 94404 USA

[16] Thomas Jefferson Univ Hosp, Div Gastroenterol & Hepatol, Philadelphia, PA USA

[17] Kings Coll Hosp London, Inst Liver Studies, London, England

[18] Univ Ulsan, Ctr Liver, Asan Med Ctr, Dept Gastroenterol,Coll Med, Ulsan, South Korea

[19] Chinese Univ Hong Kong, Dept Med & Therapeut, Inst Digest Dis, Hong Kong, Peoples R China

[20] Chinese Univ Hong Kong, Dept Med & Therapeut, State Key Lab Digest Dis, Hong Kong, Peoples R China

来源：

JOURNAL OF HEPATOLOGY | 2020年 / 73卷

关键词：

D O I：

暂无

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

AS091

引用

页码：S67 / S68

页数：2

共 50 条

[41] CORRELATIONS BETWEEN NON-INVASIVE BIOMARKERS AND FIBROSIS SCORES IN CHRONIC HEPATITIS B (CHB) PATIENTS TREATED WITH TENOFOVIR DISOPROXIL FUMARATE (TDF) AND TENOFOVIR ALAFENAMIDE (TAF) IN PHASE 3 CLINICAL TRIALS [J].

Ferret, Maria Asuncion Buti ;

Gane, Edward J. ;

Marcellin, Patrick ;

Jacobson, Ira M. ;

Janssen, Harry L. A. ;

Agarwal, Kosh ;

Fung, Scott K. ;

Chuang, Wan-Long ;

Pan, Calvin ;

Flaherty, John F. ;

Wang, Hongyuan ;

Tan, Susanna ;

Suri, Vithika ;

Gaggar, Anuj ;

Limw, Young-Suk ;

Chan, Henry Lik Yuen .

HEPATOLOGY, 2020, 72 :479A-480A

[42] Safety and Tolerability of 96 Weeks of Tenofovir Disoproxil Fumarate (TDF) Treatment in HBeAg Negative and Positive Patients Infected with Chronic Hepatitis B (CHB) [J].

Jacobson, Ira M. ;

Marcellin, Patrick ;

Heathcote, Jenny ;

Mathurin, Philippe ;

Gane, Ed J. ;

Buggisch, Peter ;

Husa, Petr ;

Krastev, Zahary ;

Sorbel, Jeff ;

Anderson, Jane ;

Mondou, Elsa ;

Rousseau, Franck .

GASTROENTEROLOGY, 2009, 136 (05) :A867-A867

[43] Safety and efficacy of switching to besifovir dipivoxil maleate in virologically-suppressed chronic hepatitis B patients with tenofovir disoproxil fumarate: 24-week interim analysis [J].

Yim, Hyung Joon ;

Kim, Ji Hoon ;

Seo, Yeon Seok ;

Kim, Won ;

Jang, Jae Young ;

Lee, Sae Hwan ;

Kim, Yun Soo ;

Kim, Chang Wook ;

Kim, Hyoung Su ;

Shim, Jae-Jun ;

Cho, Eun Young ;

Kim, In Hee ;

Lee, Byung Seok ;

Lee, Jeong-Hoon ;

Kim, Byung Seok ;

Jang, Jeong Won ;

Lee, Hyun Woong ;

Kwon, Jung Hyun ;

Kim, Moon Young ;

Song, Do Seon ;

Yoon, Eileen ;

Park, Jung Gil .

JOURNAL OF HEPATOLOGY, 2021, 75 :S743-S744

[44] IMPACT OF LONG- TERM TREATMENT WITH CONTINUOUS TENOFOVIR ALAFENAMIDE ( TAF) OR AFTER SWITCH FROM TENOFOVIR DISOPROXIL FUMARATE ( TDF) ON HEPATOCELLULAR CARCINOMA ( HCC) INCIDENCE IN PATIENTS WITH CHRONIC HEPATITIS B ( CHB) [J].

Lim, Young-Suk ;

Wong, Grace Lai-Hung C. ;

Ahn, Sang Hoon ;

Seto, Wai-Kay ;

Agarwal, Kosh ;

Janssen, Harry L. A. ;

Pan, Calvin Q. ;

Chuang, Wan Long ;

Fung, Scott K. ;

Shalimar ;

Brunetto, Maurizia R. ;

Hui, Aric Josun ;

Chang, Ting-Tsung ;

Lim, Seng Gee ;

Abramov, Frida ;

Flaherty, John F. ;

Wang, Hongyuan ;

Yee, Leland J. ;

Kao, Jia-Horng ;

Marcellin, Patrick ;

Gane, Edward J. ;

Buti, Maria .

HEPATOLOGY, 2023, 78 :S523-S526

[45] Safety and efficacy at 1 year after switching from tenofovir disoproxil fumarate to tenofovir alafenamide in chronic HBV patients with risk factors for TDF use [J].

Janssen, H. ;

Gane, E. ;

Seto, W-K ;

Caruntu, F. A. ;

Kim, H. J. ;

Abdurakhmanov, D. ;

Nishiguchi, S. ;

Horban, A. ;

Bae, H. ;

Mo, S. ;

Suri, V. ;

Gaggar, A. ;

Flaherty, J. ;

Kao, J-H ;

Brunetto, M. ;

Ferret, M. B. .

JOURNAL OF VIRAL HEPATITIS, 2018, 25 :27-27

[46] Safety and Efficacy at 1 Year after Switching from Tenofovir Disoproxil Fumarate to Tenofovir Alafenamide in Chronic HBV Patients with Risk Factors for TDF Use [J].

Gane, Edward ;

Seto, Wai Kay ;

Janssen, Harry L. A. ;

Caruntu, Florin A. ;

Kim, Hyung Joon ;

Abdurakhmanov, Dzhamal ;

Nishiguchi, Shuhei ;

Horban, Andrzej ;

Bae, Ho ;

Flaherty, John F. ;

Gaggar, Anuj ;

Suri, Vithika ;

Oberle, Corinna ;

Mo, Shuyuan ;

Subramanian, G. Mani ;

Kao, Jia-Horng ;

Brunetto, Maurizia ;

Buti, Maria .

SWISS MEDICAL WEEKLY, 2018, 148 :26S-26S

[47] Improved Bone and Renal Safety at 1 Year after Switching from Tenofovir Disoproxil Fumarate (TDF) to Tenofovir Alafenamide (TAF): Results from 2 Phase 3 Studies in HBeAg-positive and HBeAg-negative Patients with Chronic Hepatitis B (CHB) [J].

Pan, Calvin Q. ;

Brunetto, Maurizia R. ;

Hui, Aric Josun ;

Mehta, Rajiv ;

Flaherty, John F. ;

Suri, Vithika ;

Wu, George ;

Gaggar, Anuj ;

Subramanian, Mani ;

Nishiguchi, Shuhei ;

Kim, Hyung J. ;

Gane, Edward J. ;

Chuang, Wan-Long .

HEPATOLOGY, 2017, 66 :482A-482A

[48] FACTORS ASSOCIATED WITH A LACK OF VIRAL SUPPRESSION IN CHRONIC HBV ( CHB) PATIENTS AFTER 8 YEARS OF TREATMENT WITH TENOFOVIR ALAFENAMIDE ( TAF) OR TENOFOVIR DISOPROXIL FUMARATE ( TDF) FOLLOWED BY TAF TREATMENT [J].

Gane, Edward J. ;

Buti, Maria ;

Fung, Scott K. ;

Chan, Henry Lik Yuen ;

Izumi, Namiki ;

Chuang, Wan Long ;

Ahn, Sang Hoon ;

Mehta, Rajiv M. ;

Gurel, Selim ;

Abramov, Frida ;

Yee, Leland J. ;

Wang, Hongyuan ;

Mateo, Roberto ;

Flaherty, John F. ;

Ma, Xiaoli ;

Pan, Calvin Q. ;

Lim, Young-Suk ;

Marcellin, Patrick .

HEPATOLOGY, 2023, 78 :S519-S520

[49] IMPROVED BONE AND RENAL SAFETY AT 1 YEAR AFTER SWITCHING FROM TENOFOVIR DISOPROXIL FUMARATE (TDF) TO TENOFOVIR ALAFENAMIDE (TAF): RESULTS FROM 2 PHASE 3 STUDIES IN HBEAG-POSITIVE AND HBEAG-NEGATIVE PATIENTS WITH CHRONIC HEPATITIS B (CHB) [J].

Chan, Henry Lek-Yuen ;

Pan, Calvin ;

Brunetto, Maurizia ;

Hui, Aric Josun ;

Mehta, Rajiv ;

Flaherty, John F. ;

Suri, Vithika ;

Wu, George ;

Gaggar, Anuj ;

Subramanian, G. Mani ;

Nishiguchi, Shuhei ;

Kim, Hyung Joon ;

Gane, Edward ;

Chuang, Wan Long .

GUT, 2018, 67 :A97-A98

[50] Switching from tenofovir disoproxil fumarate and/or other oral antivirals to tenofovir alafenamide in virally suppressed CHB patients with moderate or severe renal impairment or ESRD on HD: final week 96 efficacy and safety results from a phase 2 study [J].

Janssen, Harry L. A. ;

Lampertico, Pietro ;

Chen, Chien-Hung ;

Heo, Jeong ;

Fournier, Claire ;

Ahn, Sang Hoon ;

Tsang, Tak Yin Owen ;

Coffin, Carla S. ;

Huang, Yi-Hsiang ;

Reggiani, Giulio Marchesini ;

Hui, Aric Josun ;

Elkhashab, Magdy ;

Chen, Chi-Yi ;

Jafri, Syed-Mohammed ;

Tan, Susanna ;

Zhao, Yang ;

Suri, Vithika ;

Flaherty, John F. ;

Gaggar, Anuj ;

Brainard, Diana ;

Chuang, Wan-Long ;

Agarwal, Kosh ;

Gane, Edward ;

Lim, Young-Suk .

JOURNAL OF HEPATOLOGY, 2021, 75 :S756-S757

← 1 2 3 4 5 →