Phenolic Glucosides from the Leaves of Vitex negundo var. cannabifolia

被引：0

作者：

Sun, Jing ^{[1
,2
]}

Li, Manman ^{[1
]}

Wang, Yongru ^{[2
]}

Chang, Chuang ^{[1
]}

Pei, Yujie ^{[1
]}

Zeng, Kewu ^{[3
]}

Zhao, Yunfang ^{[1
]}

Zheng, Jiao ^{[1
]}

Song, Yuelin ^{[1
]}

Tu, Pengfei ^{[1
]}

Huo, Huixia ^{[1
]}

Li, Jun ^{[1
]}

机构：

[1] Beijing Univ Chinese Med, Modern Res Ctr Tradit Chinese Med, Sch Chinese Mat Med, Beijing 100029, Peoples R China

[2] Chinese Acad Agr Sci, Inst Food Sci & Technol, Beijing 100193, Peoples R China

[3] Peking Univ Hlth Sci Ctr, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

来源：

CHEMISTRY & BIODIVERSITY | 2022年 / 19卷 / 11期

基金：

国家重点研发计划;

关键词：

Verbenaceae; Vitex negundo var; cannabifolia; phenolic glucosides; anti-inflammation; CONSTITUENTS;

D O I：

10.1002/cbdv.202200652

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Four new phenolic glucosides, cannabifolins G-J (1-4), together with four known ones (5-8), were isolated from the leaves of Vitex negundo var. cannabifolia. Their structures were established by comprehensive analysis of 1D and 2D NMR data and comparison of their spectroscopic and physical data with the literature values. Compound 7 exhibited weak inhibition of nitric oxide production stimulated by lipopolysaccharide in BV-2 microglial cells with IC50 value of 132.8 mu M.

引用

页数：7

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