The Prognostic Value of Angiogenic Markers in Twin Pregnancies to Predict Delivery Due to Maternal Complications of Preeclampsia

被引：22

作者：

Binder, Julia ^{[1
]}

Palmrich, Pilar ^{[1
]}

Pateisky, Petra ^{[1
]}

Kalafat, Erkan ^{[2
,3
]}

Kussel, Lorenz ^{[1
]}

Zeisler, Harald ^{[1
]}

Munkhbaatar, March ^{[1
]}

Windsperger, Karin ^{[1
]}

Thilaganathan, Basky ^{[4
,5
]}

Khalil, Asma ^{[4
,5
]}

机构：

[1] Med Univ Vienna, Dept Obstet & Fetomaternal Med, Wahringer Gurtel 18-20, A-1090 Vienna, Austria

[2] Middle East Tech Univ Ankara, Fac Arts & Sci, Dept Stat, Ankara, Turkey

[3] Ankara Univ, Dept Obstet & Gynecol, Ankara, Turkey

[4] St Georges Univ London, St Georges Hosp, Fetal Med Unit, London, England

[5] St Georges Univ London, Mol & Clin Sci Res Inst, Vasc Biol Res Ctr, London, England

来源：

HYPERTENSION | 2020年 / 76卷 / 01期

关键词：

angiogenic markers; hypertension; suspected preeclampsia; twin pregnancy; ADVERSE OUTCOMES; WOMEN; RATIO; RISK;

D O I：

10.1161/HYPERTENSIONAHA.120.14957

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

The sFlt-1 (soluble fms-like tyrosine kinase-1), PlGF (placental growth factor), and their ratio are useful for predicting delivery because of preeclampsia in singleton pregnancies. Evidence on the utility of sFlt-1/PlGF ratio in twin pregnancies is lacking. We aimed to evaluate the predictive value of sFlt-1/PlGF ratio for delivery because of preeclampsia in twins. A retrospective data analysis of 164 twin pregnancies with suspected preeclampsia was performed. The sFlt-1/PlGF ratio, which was known to clinicians, was significantly higher in women who delivered within 1 and 2 weeks compared with those who did not (median: 98.9 and 84.2 versus 23.5 pg/mL, respectively;P<0.001). The area under the curve values sFlt-1/PlGF ratio levels were 0.88 (95% CI, 0.83-0.84) and 0.88 (95% CI, 0.83-0.93) for predicting delivery because of preeclampsia within 1 and 2 weeks of blood sampling, respectively. The predictive accuracy of sFlt-1/PlGF was independent of gestational age at sampling and chorionicity (P>0.100 for interaction). The area under the curve values of sFlt-1/PlGF were significantly higher than for PlGF alone (mean 0.88 and 0.88 versus 0.81 and 0.80) for predicting delivery because of preeclampsia within 1 and 2 weeks of blood sampling (P=0.055 and 0.001, respectively). sFlt-1/PlGF ratio lower than 38 was able to rule-out delivery within 1 and 2 weeks with a negative predictive value of 98.8% and 96.4% for delivery because of preeclampsia within 1 and 2 weeks, respectively. A cutoff of 38 is applicable for ruling out delivery because of preeclampsia in twin pregnancies.

引用

页码：176 / 183

页数：8

共 25 条

[1] Maternal near-miss and death among women with hypertensive disorders in pregnancy: a secondary analysis of the Nigeria Near-miss and Maternal Death Survey [J].