Nucleation of the β-hairpin structure in a linear hybrid peptide containing α-, β- and γ-amino acids

被引：5

作者：

Chakraborty, Tushar K. ^{[1
]}

Rao, K. Srinivasa ^{[1
]}

Kiran, M. Udaya ^{[1
]}

Jagadeesh, B.

机构：

[1] Indian Inst Chem Technol, Hyderabad 500007, Andhra Pradesh, India

来源：

TETRAHEDRON LETTERS | 2008年 / 49卷 / 14期

关键词：

peptide mimetics; pyrrole amino acid; furan amino acid; hydrogen bonding; conformation; NMR;

D O I：

10.1016/j.tetlet.2008.02.048

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthesis and conformational studies of a short linear peptide containing a pyrrole amino acid (1, Paa) and a furan amino acid (2, Faa), namely Boc-hGly-Faa-D-Pro-Gly-Paa-hGly-Faa-OMe (3), were carried out in which it was established that peptide 3 adopted a well-defined P-hairpin structure in DMSC-d(6). (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：2228 / 2231

页数：4

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