Temperature-sensitive nanogels: poly(N-vinylcaprolactam) versus poly(N-isopropylacrylamide)

被引：255

作者：

Ramos, Jose ^{[2
]}

Imaz, Ainara ^{[1
]}

Forcada, Jacqueline ^{[1
]}

机构：

[1] Univ Pais Vasco EHU, Dept Quim Aplicada, Fac Ciencias Quim, Grp Ingn Quim, Donostia San Sebastian 20080, Spain

[2] Univ Granada, Fac Ciencias, Dept Fis Aplicada, Grp Fis Fluidos & Biocoloides, E-18071 Granada, Spain

来源：

POLYMER CHEMISTRY | 2012年 / 3卷 / 04期

关键词：

VINYLCAPROLACTAM-BASED MICROGELS; VOLUME PHASE-TRANSITION; N-ISOPROPYLACRYLAMIDE; THERMOSENSITIVE POLYMERS; BIOMEDICAL APPLICATIONS; COPOLYMER MICROGELS; ACRYLATE) MICROGELS; LATEX FORMATION; PARTICLES; PH;

D O I：

10.1039/c2py00485b

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Poly(N-isopropylacrylamide) (PNIPAM) and poly(N-vinylcaprolactam) (PVCL) are temperature-responsive polymers which show a lower critical solution temperature (LCST) around 32 degrees C in aqueous solutions. Nanogels based on these temperature sensitive polymers swell at low temperatures and collapse at high ones, showing a volume phase transition temperature (VPTT) near physiological temperature. This unique behavior makes these nanogels attractive for biotechnological applications. PNIPAM is the building block of a huge amount of nanogels reported in the literature. However, PVCL is especially interesting due to the fact that it is very stable against hydrolysis and biocompatible. In this mini-review, various synthesis procedures together with the functionalization of different PNIPAM-and PVCL-based nanogels are revised and compared.

引用

页码：852 / 856

页数：5

共 54 条

[1] Thermoresponsive poly(N-vinyl caprolactam)-coated gold nanoparticles: sharp reversible response and easy tunability [J].