Is there a role for antibiotics in the treatment of chronic rhinosinusitis?

被引：19

作者：

Smith, Stephanie Shintani ^{[1
,2
]}

Kim, Raymond ^{[3
]}

Douglas, Richard ^{[3
]}

机构：

[1] Northwestern Univ, Feinberg Sch Med, Dept Otolaryngol Head & Neck Surg, 676 N St Clair,Ste 1325, Chicago, IL 60607 USA

[2] Northwestern Univ, Feinberg Sch Med, Ctr Hlth Serv & Outcomes Res, Inst Publ Hlth & Med, Chicago, IL 60607 USA

[3] Univ Auckland, Dept Surg, Auckland, New Zealand

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2022年 / 149卷 / 05期

基金：

美国国家卫生研究院;

关键词：

Chronic rhinosinusitis; antibiotics; review article; ENDOSCOPIC SINUS SURGERY; PLACEBO-CONTROLLED TRIAL; MAXIMAL MEDICAL THERAPY; STAPHYLOCOCCUS-AUREUS; DOUBLE-BLIND; CYSTIC-FIBROSIS; NASAL POLYPS; PSEUDOMONAS-AERUGINOSA; LONG-TERM; MACROLIDE ANTIBIOTICS;

D O I：

10.1016/j.jaci.2022.02.004

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Rhinosinusitis is one of the most common reasons for adult outpatient antibiotic prescriptions, though there is little clinical evidence to support this practice, especially for chronic rhinosinusitis. Despite considerable research, the etiology of chronic rhinosinusitis, including the pathogenic role of microbes, remains poorly understood. Rigorous studies of the efficacy of antibiotic treatment of chronic sinusitis are surprisingly few in number and the results are somewhat conflicting. This review article will review the rationales for and against the treatment of chronic rhinosinusitis with antibiotics, based on current evidence and understanding of pathophysiology, and will also summarize the current guidelines.

引用

页码：1504 / 1512

页数：9

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