New Horizons in Microbiota and Metabolic Health Research

被引：5

作者：

Mishra, Sidharth P. ^{[1
,2
]}

Jain, Shalini ^{[3
,4
]}

Taraphder, Subhash ^{[2
]}

Yadav, Hariom ^{[1
]}

机构：

[1] Wake Forest Sch Med, Dept Internal Med Mol Med, Winston Salem, NC 27101 USA

[2] West Bengal Univ Anim & Fishery Sci, Dept Anim Genet & Breeding, Kolkata 700037, W Bengal, India

[3] Wake Forest Sch Med, Metab Phenotyping Shared Resource, Winston Salem, NC 27101 USA

[4] Wake Forest Sch Med, Dept Internal Med Endocrinol, Winston Salem, NC 27101 USA

来源：

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | 2021年 / 106卷 / 02期

基金：

美国国家卫生研究院;

关键词：

microbiota; gut; metabolic; diabetes; obesity; inflammation; brain; GUT MICROBIOTA; HYPOTHALAMUS; INFLAMMATION; EXPRESSION; METFORMIN; AXIS;

D O I：

10.1210/clinem/dgaa769

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Decade-old studies have demonstrated that microbes living in our gut (microbiota) contribute to both maintaining normal metabolic function and to the pathology of metabolic diseases, such as obesity and diabetes. Emerging evidence suggests that gut microbiota influences the personalized effects of diets and drugs and impact the gut-brain axis and leaky gut inflammation to control metabolic function/diseases. Gut microbiota can be an ideal source of prognostic markers and therapies for metabolic diseases. Here we discuss the emerging concepts in the area of microbiota and metabolic interactions in personalized nutrition, drug response, and disease prognosis.

引用

页码：E1052 / E1059

页数：8

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