Low-dose Cytosine arabinoside; disease free survival and overall survival in the elderly patients with Acute Myeloid Leukemia

被引:0
|
作者
Sanaat, Zohreh [1 ]
Najafi, Amin [1 ]
机构
[1] Tabriz Univ Med Sci, Hematol & Oncol Res Ctr, Ghazi Tabatabae Hosp, Tabriz, Iran
关键词
Acute myeloid leukemia; Low-dose Cytosine arabinoside; Disease-free survival; Overall survival; Flowcytometry; Elderly AML; ACUTE NONLYMPHOCYTIC LEUKEMIA; MYELODYSPLASTIC SYNDROMES; ARA-C; CYTARABINE; THERAPY;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objectives: The median age of the patients with acute myeloid leukemia (AML) is 65 years. Studies have revealed that the prognosis of the elderly patients (over 60 years) is not satisfying. The aim of this study was to evaluate the survival of AML patients being treated with Low-dose Cytosine arabinoside. Methodology: In this cross-sectional study, 20 AML patients treated with Low-dose Cytosine arabinoside. Disease free survival and overall five-year survival ratios were identified. Results: In this study there were 11 males (55%) and nine female (45%) with a mean age of 63.3 +/- 18.4 years. The median of disease free survival was 12.4 months and five-year survival was 1.7 years. Conclusion: Apparently disease-free survival and overall five-year survival in the AML patients being treated with Low-dose Cytosine arabinoside are similar to that of cases being treated with intense chemotherapy regimens.
引用
收藏
页码:1211 / 1213
页数:3
相关论文
共 50 条
  • [1] Cytosine arabinoside, idarubicin and divided dose etoposide for the treatment of acute myeloid leukemia in elderly patients
    Hartmann, F
    Jacobs, G
    Gotto, H
    Schwamborn, J
    Pfreundschuh, M
    LEUKEMIA & LYMPHOMA, 2001, 42 (03) : 347 - 355
  • [2] LOW-DOSE CYTOSINE-ARABINOSIDE FOR TREATING HYPOCELLULAR ACUTE-LEUKEMIA IN THE ELDERLY
    KANAMORI, H
    MARUTA, A
    MIYASHITA, H
    HARANO, H
    FUKAWA, H
    MATSUZAKI, M
    MOTOMURA, S
    MOHRI, H
    KODAMA, F
    OKUBO, T
    AMERICAN JOURNAL OF HEMATOLOGY, 1992, 39 (01) : 52 - 55
  • [3] IS THERE STILL A ROLE FOR LOW-DOSE CYTOSINE-ARABINOSIDE IN DENOVO ACUTE MYELOID-LEUKEMIA IN THE ELDERLY - A REPORT ON 77 CASES
    DETOURMIGNIES, L
    WATTEL, E
    LAI, JL
    BAUTERS, F
    FENAUX, P
    ANNALS OF HEMATOLOGY, 1993, 66 (05) : 235 - 240
  • [4] RESULTS OF CONVENTIONAL-DOSE CYTOSINE-ARABINOSIDE AND IDARUBICIN IN ELDERLY PATIENTS WITH ACUTE MYELOID-LEUKEMIA
    HEYLL, A
    AUL, C
    GOGOLIN, F
    RUNDE, V
    SOHNGEN, D
    MECKENSTOCK, G
    WOLF, HH
    ZAHNER, J
    BURK, M
    WINKELMANN, M
    SCHNEIDER, W
    ANNALS OF HEMATOLOGY, 1994, 68 (06) : 279 - 283
  • [5] Effect of high dose cytosine arabinoside on quantitative EEG in patients with acute myeloid leukemia
    Maschio, Marta
    Marchesi, Francesco
    Dispenza, Sabrina
    Dinapoli, Loredana
    Sperati, Francesca
    Petreri, Gianluca
    Gumenyuk, Svitlana
    Dessanti, Maria Laura
    Zarabla, Alessia
    Cantelmi, Tonino
    Mengarelli, Andrea
    COGNITIVE NEURODYNAMICS, 2016, 10 (02) : 185 - 188
  • [6] Stage I of a phase 2 study assessing the efficacy, safety, and tolerability of barasertib (AZD1152) versus low-dose cytosine arabinoside in elderly patients with acute myeloid leukemia
    Kantarjian, Hagop M.
    Martinelli, Giovanni
    Jabbour, Elias J.
    Quintas-Cardama, Alfonso
    Ando, Kiyoshi
    Bay, Jacques-Olivier
    Wei, Andrew
    Groepper, Stefanie
    Papayannidis, Cristina
    Owen, Kate
    Pike, Laura
    Schmitt, Nicola
    Stockman, Paul K.
    Giagounidis, Aristoteles
    CANCER, 2013, 119 (14) : 2611 - 2619
  • [7] Myeloid sarcoma is associated with superior event-free survival and overall survival compared with acute myeloid leukemia
    Tsimberidou, Apostolia-Maria
    Kantarjian, Hagop M.
    Wen, Sijin
    Keating, Michael J.
    O'Brien, Susan
    Brandt, Mark
    Pierce, Sherry
    Freireieh, Emil J.
    Medeiros, L. Jeffrey
    Estey, Elihu
    CANCER, 2008, 113 (06) : 1370 - 1378
  • [9] Effect of high dose cytosine arabinoside on quantitative EEG in patients with acute myeloid leukemia
    Marta Maschio
    Francesco Marchesi
    Sabrina Dispenza
    Loredana Dinapoli
    Francesca Sperati
    Gianluca Petreri
    Svitlana Gumenyuk
    Maria Laura Dessanti
    Alessia Zarabla
    Tonino Cantelmi
    Andrea Mengarelli
    Cognitive Neurodynamics, 2016, 10 : 185 - 188
  • [10] Leukemia-free survival as a surrogate end point for overall survival in the evaluation of maintenance therapy for patients with acute myeloid leukemia in complete remission
    Buyse, Marc
    Michiels, Stefan
    Squifflet, Pierre
    Lucchesi, Kathryn J.
    Hellstrand, Kristoffer
    Brune, Mats L.
    Castaigne, Sylvie
    Rowe, Jacob M.
    HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2011, 96 (08): : 1106 - 1112