From skeletal muscle to cancer: Insights learned elucidating the function of tropomyosin

被引：25

作者：

Choi, Cheolwon ^{[1
]}

Kim, Dayoung ^{[1
]}

Kim, Sabina ^{[2
]}

Jeong, SukYeong ^{[1
]}

Song, Eunsol ^{[1
]}

Helfman, David M. ^{[1
,2
]}

机构：

[1] Korea Adv Inst Sci & Technol, Dept Biol Sci, Taejon 305701, South Korea

[2] Korea Adv Inst Sci & Technol, Grad Sch Nanosci & Technol WCU, Taejon 305701, South Korea

来源：

JOURNAL OF STRUCTURAL BIOLOGY | 2012年 / 177卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

Tropomyosin; Cytoskeleton; Cell motility; Cancer; Coiled-coil; MOLECULAR-WEIGHT TROPOMYOSINS; RAS-TRANSFORMED FIBROBLASTS; CHICKEN-EMBRYO FIBROBLASTS; SIGNAL-REGULATED KINASE; TUMOR-SUPPRESSOR; NONMUSCLE TROPOMYOSIN; ACTIN CYTOSKELETON; TGF-BETA; ISOFORM EXPRESSION; OXIDATIVE STRESS;

D O I：

10.1016/j.jsb.2011.11.016

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The tropomyosins (Tms) are a family of actin filament binding proteins that possess a simple dimeric alpha-helical coiled-coil structure along their entire length. Our knowledge of Tm structure and function has greatly expanded since they were first discovered in skeletal muscle almost 65 years ago. In multicellular organisms they exhibit extensive cell type specific isoform diversity. In this essay we discuss the genetic mechanisms by which this diversity is generated and its significance to actin-based cellular functions. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：63 / 69

页数：7

共 75 条

[1] TROPOMYOSIN - A NEW ASYMMETRIC PROTEIN COMPONENT OF THE MUSCLE FIBRIL [J].

BAILEY, K .

BIOCHEMICAL JOURNAL, 1948, 43 (02) :271-&

[2] A critical role of tropomyosins in TGF-β regulation of the actin cytoskeleton and cell motility in epithelial cells [J].

Bakin, AV ;

Safina, A ;

Rinehart, C ;

Daroqui, C ;

Darbary, H ;

Helfman, DM .

MOLECULAR BIOLOGY OF THE CELL, 2004, 15 (10) :4682-4694

[3] Resensitization of breast cancer cells to anoikis by Tropomyosin-1: role of Rho kinase-dependent cytoskeleton and adhesion [J].

Bharadwaj, S ;

Thanawala, R ;

Bon, G ;

Falcioni, R ;

Prasad, GL .

ONCOGENE, 2005, 24 (56) :8291-8303

[4] Tropomyosin-1, a novel suppressor of cellular transformation is downregulated by promoter methylation in cancer cells [J].

Bharadwaj, S ;

Prasad, GL .

CANCER LETTERS, 2002, 183 (02) :205-213

[5]

Bharadwaj S, 2008, J CANC MOL, V4, P139

[6] Inhibition of the Arp2/3 complex-nucleated actin polymerization and branch formation by tropomyosin [J].

Blanchoin, L ;

Pollard, TD ;

Hitchcock-DeGregori, SE .

CURRENT BIOLOGY, 2001, 11 (16) :1300-1304

[7]

Braverman RH, 1996, ONCOGENE, V13, P537

[8] Specification of actin filament function and molecular composition by tropomyosin isoforms [J].

Bryce, NS ;

Schevzov, G ;

Ferguson, V ;

Percival, JM ;

Lin, JJC ;

Matsumura, F ;

Bamburg, JR ;

Jeffrey, PL ;

Hardeman, EC ;

Gunning, P ;

Weinberger, RP .

MOLECULAR BIOLOGY OF THE CELL, 2003, 14 (03) :1002-1016

[9] How tropomyosin regulates lamellipodial actin-based motility: a combined biochemical and reconstituted motility approach [J].

Bugyi, Beata ;

Didry, Dominique ;

Carlier, Marie-France .

EMBO JOURNAL, 2010, 29 (01) :14-26

[10] MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells [J].

Chan, JA ;

Krichevsky, AM ;

Kosik, KS .

CANCER RESEARCH, 2005, 65 (14) :6029-6033

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