Bioinorganic models for the catalytic cooperation of metal ions and functional groups in nuclease and peptidase enzymes

被引:175
|
作者
Krämer, R [1 ]
机构
[1] Univ Munster, Inst Anorgan Chem, D-48149 Munster, Germany
关键词
peptidases; enzymes; catalysis;
D O I
10.1016/S0010-8545(98)00235-5
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
Many nuclease and peptidase enzymes achieve highly efficient catalysis by active site cooperation of metal ions and amino acid side chains (acids, bases or nucleophiles). This review focuses on model complexes for which attachment of functional organic groups to a chelate ligand results in an increased hydrolytic reactivity toward phosphodiesters and amides. (C) 1999 Elsevier Science S.A. All rights reserved.
引用
收藏
页码:243 / 261
页数:19
相关论文
共 50 条
  • [1] Mimicking enzymes: Cooperation between organic functional groups and metal ions in the cleavage of phosphate diesters
    Livieri, Monica
    Mancin, Fabrizio
    Saielli, Giacomo
    Chin, Jik
    Tonellato, Umberto
    CHEMISTRY-A EUROPEAN JOURNAL, 2007, 13 (08) : 2246 - 2256
  • [2] Metal clusters toward bioinorganic models and functional materials
    Vaddypally, Shivaiah
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2013, 246
  • [3] HYDROXO COMPLEXES OF TRANSITION METAL IONS AS MODELS OF HYDROLYTIC METAL ENZYMES
    WERBER, M
    SHALITIN, Y
    ISRAEL JOURNAL OF CHEMISTRY, 1967, 5 (4A) : P89 - &
  • [4] Structure of the I-SceI nuclease complexed with its dsDNA target and three catalytic metal ions
    Prieto, Jesus
    Redondo, Pilar
    Merino, Nekane
    Villate, Maider
    Montoya, Guillermo
    Blanco, Francisco J.
    Molina, Rafael
    ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 2016, 72 : 473 - 479
  • [5] Application of resins with functional groups in the separation of metal ions/species - a review
    Silva, Rene A.
    Hawboldt, Kelly
    Zhang, Yahui
    MINERAL PROCESSING AND EXTRACTIVE METALLURGY REVIEW, 2018, 39 (06): : 395 - 413
  • [6] Adsorption of metal ions on nitrogen surface functional groups in activated carbons
    Jia, YF
    Xiao, B
    Thomas, KM
    LANGMUIR, 2002, 18 (02) : 470 - 478
  • [7] OUTER-SPHERE ACTIVATION OF FUNCTIONAL-GROUPS BY METAL-IONS
    YEH, GC
    ROHDE, AM
    BASHKIN, JK
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1995, 210 : 561 - INOR
  • [8] CATALYTIC DETERMINATIONS OF ENZYMES AND METAL-IONS BY SAMPLE INJECTION IN CLOSED-LOOP FLOW SYSTEMS
    RAMASAMY, SM
    IOB, A
    MOTTOLA, HA
    ANALYTICAL CHEMISTRY, 1979, 51 (11) : 1637 - 1639
  • [9] A Trypsin from Euphausia Pacifica (TEP B): Functional Groups and Effects of Metal Ions
    Xiang, Peng
    Wu, Zhiqiang
    Niu, Wentao
    Ye, Youyin
    Lin, Mao
    JOURNAL OF COASTAL RESEARCH, 2018, : 392 - 396
  • [10] Chemical modification of silica surface by immobilization of functional groups for extractive concentration of metal ions
    Jal, PK
    Patel, S
    Mishra, B
    TALANTA, 2004, 62 (05) : 1005 - 1028