p125/Sec23-interacting protein (Sec23ip) is required for spermiogenesis

被引：22

作者：

Arimitsu, Nagisa ^{[1
]}

Kogure, Takeshi ^{[1
]}

Baba, Takashi ^{[1
]}

Nakao, Kazuki ^{[2
]}

Hamamoto, Hiroshi ^{[3
]}

Sekimizu, Kazuhisa ^{[3
]}

Yamamoto, Akitsugu ^{[4
]}

Nakanishi, Hiroki ^{[5
,6
]}

Taguchi, Ryo ^{[5
,6
]}

Tagaya, Mitsuo ^{[1
]}

Tani, Katsuko ^{[1
]}

机构：

[1] Tokyo Univ Pharm & Life Sci, Sch Life Sci, Tokyo 1920392, Japan

[2] RIKEN Ctr Dev Biol, Chuo Ku, Kobe, Hyogo 6500047, Japan

[3] Univ Tokyo, Dept Dev Biochem, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan

[4] Nagahama Inst Biosci & Technol, Fac Biosci, Shiga 5260829, Japan

[5] Univ Tokyo, Dept Metabolome, Grad Sch Med, Bunkyo Ku, Tokyo 1130033, Japan

[6] Core Res Evolut Sci & Technol, Kawaguchi, Saitama 3320012, Japan

来源：

FEBS LETTERS | 2011年 / 585卷 / 14期

关键词：

COPII; Endoplasmic reticulum exit site; Sec23; Spermiogenesis; MAMMALIAN SEC23P-INTERACTING PROTEIN; PHOSPHOLIPASE A(1); SHOOT GRAVITROPISM; ACROSOME FORMATION; MALE-INFERTILITY; P125; MODELS; MICE;

D O I：

10.1016/j.febslet.2011.05.050

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

p125/Sec23ip is a phospholipase A(1)-like protein that interacts with Sec23, a coat component of COPII vesicles that bud from endoplasmic reticulum exit sites. To understand its physiological function, we produced p125 knockout mice. The p125 knockout mice grew normally, but males were subfertile. Sperm from p125-deficient mice had round heads and lacked the acrosome, an organelle containing the enzymes responsible for fertilization. p125 was found to be expressed at stages I-XII of spermatogenesis, similar to the expression pattern of proteins involved in acrosome biogenesis. These results suggest that p125 plays an important role in spermiogenesis. Structured summary of protein interactions: p125 and Sec31A colocalize by fluorescence microscopy (View interaction) (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：2171 / 2176

页数：6

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