Dynamic modulation of proximity-induced enzyme activity using supramolecular polymers

被引：4

作者：

Estirado, Eva Magdalena ^{[1
,2
]}

Rosier, Bas J. H. M. ^{[1
,2
]}

de Greef, Tom F. A. ^{[1
,2
,3
,4
]}

Brunsveld, Luc ^{[1
,2
]}

机构：

[1] Eindhoven Univ Technol, Lab Chem Biol, POB 513, NL-5600 MB Eindhoven, Netherlands

[2] Eindhoven Univ Technol, Inst Complex Mol Syst, POB 513, NL-5600 MB Eindhoven, Netherlands

[3] Eindhoven Univ Technol, Computat Biol Grp, Dept Biomed Engn, POB 513, NL-5600 MB Eindhoven, Netherlands

[4] Radboud Univ Nijmegen, Inst Mol & Mat, Nijmegen, Netherlands

来源：

CHEMICAL COMMUNICATIONS | 2020年 / 56卷 / 43期

基金：

欧盟地平线“2020”;

关键词：

SCAFFOLD PROTEINS; ACTIVATION; APOPTOSOME; DOMAINS; BINDING;

D O I：

10.1039/d0cc02120b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Synthetic supramolecular polymers are used as dynamic nanoscaffolds for the activation of the apoptotic signalling enzyme caspase-9. Recruitment of caspase-9 to the nanoscaffold results in an increase in enzymatic activity due to enhanced proximity, with a bell-shaped response as a function of nanoscaffold concentration. The modularity of the system allows for dynamic regulation of enzyme activity through variation of the recruitment-motif density along the supramolecular polymer.

引用

页码：5747 / 5750

页数：4

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