S100A6 promotes proliferation of intrahepatic cholangiocarcinoma cells via the activation of the p38/MAPK pathway

被引：13
|
作者：
Zheng, Susu [1 ,2 ]
Shen, Hujia [1 ,2 ]
Jia, Qingan [1 ,2 ]
Jing, Chuyu [1 ,2 ]
Lin, Jiajia [1 ,2 ]
Zhang, Meixia [1 ,2 ]
Zhang, Xiaolei [3 ]
Zhang, Boheng [1 ,2 ]
Liu, Yinkun [1 ,2 ]
机构：
[1] Fudan Univ, Liver Canc Inst, Dept Hepat Oncol, Shanghai 20032, Peoples R China
[2] Fudan Univ, Zhongshan Hosp, Shanghai 20032, Peoples R China
[3] Fudan Univ, Zhongshan Hosp, Dept Pathol, Shanghai 20032, Peoples R China
来源：
FUTURE ONCOLOGY | 2017年 / 13卷 / 23期
基金：
中国国家自然科学基金;
关键词：
intrahepatic cholangiocarcinoma; prognosis; proliferation; S100A6; HUMAN HEPATOCELLULAR-CARCINOMA; GASTRIC-CANCER; THERAPEUTIC TARGET; MAPK PATHWAYS; EXPRESSION; PROTEIN; KINASE; CALCYCLIN; MIGRATION; GROWTH;
D O I：
10.2217/fon-2017-0199
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Aim: We explored the expression of S100A6 and its role in intrahepatic cholangiocarcinoma (ICC). Methods: The expression of S100A6 in ICC samples was detected by immunohistochemistry. In vitro experiments, we silenced and overexpressed S100A6 to investigate its role in cell functions. Results: The expression of S100A6 was markedly increased in ICC tissues and cell lines. S100A6 overexpression was an independent risk factor for patients' survival. Silencing S100A6 resulted in a suppression of proliferation and p38/MAPK activity, while overexpressing S100A6 caused a promotion of proliferation and p38/MAPK. Discussion: S100A6 participated in the proliferation of ICC cells and correlated with a more aggressive behavior of ICC. Conclusion: S100A6 may serve as a novel prognostic marker and a potential therapeutic target for ICC patients.
引用
收藏
页码：2053 / 2063
页数：11
相关论文
共 50 条
  • [41] N-(4-hydroxyphenyl) retinamide inhibits migration of renal carcinoma cells and promotes autophagy via MAPK p38 pathway
    Gao, Jianguo
    Tang, Jianer
    Chen, Yu
    Shen, Junwen
    Wang, Ning
    Fang, Zhihai
    Shen, Guiqin
    Ren, Fan
    Wang, Rongjiang
    TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH, 2018, 17 (06) : 1003 - 1009
  • [42] Puerarin inhibits vascular smooth muscle cells proliferation induced by fine particulate matter via suppressing of the p38 MAPK signaling pathway
    Wan, Qiang
    Liu, Zhongyong
    Yang, Yuping
    BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2018, 18
  • [43] Carbonic anhydrase XII promotes invasion and migration ability of MDA-MB-231 breast cancer cells through the p38 MAPK signaling pathway
    Hsieh, Ming-Ju
    Chen, Kuo-Shuen
    Chiou, Hui-Ling
    Hsieh, Yih-Shou
    EUROPEAN JOURNAL OF CELL BIOLOGY, 2010, 89 (08) : 598 - 606
  • [44] ST6Gal-I modulates docetaxel sensitivity in human hepatocarcinoma cells via the p38 MAPK/caspase pathway
    Chen, Xixi
    Wang, Liping
    Zhao, Yujie
    Yuan, Shiqi
    Wu, Qiang
    Zhu, Xiaoling
    Niang, Bachir
    Wang, Shujing
    Zhang, Jianing
    ONCOTARGET, 2016, 7 (32) : 51955 - 51964
  • [45] Proliferative Vascular Smooth Muscle Cells Stimulate Extracellular Matrix Production via Osteopontin/p38 MAPK Signaling Pathway
    Pei, Huawei
    Zhang, Haiyue
    Tian, Chuan
    Sun, Xiaogang
    Qian, Xiangyang
    Meng, Yanhai
    Guo, Xiaobo
    Chang, Qian
    CARDIOLOGY, 2021, 146 (05) : 646 - 655
  • [46] UCP2 silencing in glioblastoma reduces cell proliferation and invasiveness by inhibiting p38 MAPK pathway
    Wu, Shuai
    Luo, Chen
    Hameed, N. U. Farrukh
    Wang, Ye
    Zhuang, Dongxiao
    EXPERIMENTAL CELL RESEARCH, 2020, 394 (01)
  • [47] ZIP14 Affects the Proliferation, Apoptosis, and Migration of Cervical Cancer Cells by Regulating the P38 MAPK Pathway
    Jiang, Lixia
    Xie, Ting
    Xia, Yu
    Li, Feng
    Zhong, Tianyu
    Lai, Mi
    CURRENT CANCER DRUG TARGETS, 2024, 24 (08) : 779 - 790
  • [48] HOXA5 overexpression promotes osteosarcoma cell apoptosis through the p53 and p38α MAPK pathway
    Chen, Yan-Qiang
    Yang, Tong-Qun
    Zhou, Bin
    Yang, Ming-Xuan
    Feng, Hai-Jun
    Wang, Yu-Liang
    GENE, 2019, 689 : 18 - 23
  • [49] Metformin potentiates the effect of arsenic trioxide suppressing intrahepatic cholangiocarcinoma: roles of p38 MAPK, ERK3, and mTORC1
    Ling, Sunbin
    Xie, Haiyang
    Yang, Fan
    Shan, Qiaonan
    Dai, Haojiang
    Zhuo, Jianyong
    Wei, Xuyong
    Song, Penghong
    Zhou, Lin
    Xu, Xiao
    Zheng, Shusen
    JOURNAL OF HEMATOLOGY & ONCOLOGY, 2017, 10 : 59
  • [50] S100A6 promotes proliferation and migration of HepG2 cells via increased ubiquitin-dependent degradation of p53
    Song, Dongqiang
    Xu, Beili
    Shi, Dongmin
    Li, Shuyu
    Cai, Yu
    OPEN MEDICINE, 2020, 15 (01): : 317 - 326
12345