S100A6 promotes proliferation of intrahepatic cholangiocarcinoma cells via the activation of the p38/MAPK pathway

被引：13
|
作者：
Zheng, Susu [1 ,2 ]
Shen, Hujia [1 ,2 ]
Jia, Qingan [1 ,2 ]
Jing, Chuyu [1 ,2 ]
Lin, Jiajia [1 ,2 ]
Zhang, Meixia [1 ,2 ]
Zhang, Xiaolei [3 ]
Zhang, Boheng [1 ,2 ]
Liu, Yinkun [1 ,2 ]
机构：
[1] Fudan Univ, Liver Canc Inst, Dept Hepat Oncol, Shanghai 20032, Peoples R China
[2] Fudan Univ, Zhongshan Hosp, Shanghai 20032, Peoples R China
[3] Fudan Univ, Zhongshan Hosp, Dept Pathol, Shanghai 20032, Peoples R China
来源：
FUTURE ONCOLOGY | 2017年 / 13卷 / 23期
基金：
中国国家自然科学基金;
关键词：
intrahepatic cholangiocarcinoma; prognosis; proliferation; S100A6; HUMAN HEPATOCELLULAR-CARCINOMA; GASTRIC-CANCER; THERAPEUTIC TARGET; MAPK PATHWAYS; EXPRESSION; PROTEIN; KINASE; CALCYCLIN; MIGRATION; GROWTH;
D O I：
10.2217/fon-2017-0199
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Aim: We explored the expression of S100A6 and its role in intrahepatic cholangiocarcinoma (ICC). Methods: The expression of S100A6 in ICC samples was detected by immunohistochemistry. In vitro experiments, we silenced and overexpressed S100A6 to investigate its role in cell functions. Results: The expression of S100A6 was markedly increased in ICC tissues and cell lines. S100A6 overexpression was an independent risk factor for patients' survival. Silencing S100A6 resulted in a suppression of proliferation and p38/MAPK activity, while overexpressing S100A6 caused a promotion of proliferation and p38/MAPK. Discussion: S100A6 participated in the proliferation of ICC cells and correlated with a more aggressive behavior of ICC. Conclusion: S100A6 may serve as a novel prognostic marker and a potential therapeutic target for ICC patients.
引用
收藏
页码：2053 / 2063
页数：11
相关论文
共 50 条
  • [21] PSKH1 affects proliferation and invasion of osteosarcoma cells via the p38/MAPK signaling pathway
    Zhu, Xingfei
    Jiang, Chao
    Wang, Zhiyuang
    Zhu, Xiaozhong
    Yuan, Feng
    Yang, Yi
    ONCOLOGY LETTERS, 2023, 25 (04)
  • [22] TMBIM1 promotes proliferation and attenuates apoptosis in glioblastoma cells by targeting the p38 MAPK signalling pathway
    Cai, Jiayang
    Gao, Lun
    Wang, Yixuan
    Li, Yong
    Ye, Zhang
    Tong, Shiao
    Yan, Tengfeng
    Sun, Qian
    Xu, Yang
    Jiang, Hongxiang
    Zhang, Si
    Zhao, Linyao
    Yang, Ji'an
    Chen, Qianxue
    TRANSLATIONAL ONCOLOGY, 2022, 19
  • [23] Ginkgetin inhibits proliferation of HeLa cells via activation of p38/NF-κB pathway
    Cheng, Jianxia
    Li, Yun
    Kong, Jianping
    CELLULAR AND MOLECULAR BIOLOGY, 2019, 65 (04) : 79 - 82
  • [24] MPP8 Promotes Proliferation and Restrains Apoptosis in Osteosarcoma by Regulating p38αMAPK Pathway
    Li, Tao
    Li, Na
    Wang, Lei
    Li, Jia
    Zhang, Xin
    TECHNOLOGY IN CANCER RESEARCH & TREATMENT, 2021, 20
  • [25] Syntenin regulates melanogenesis via the p38 MAPK pathway
    Sun, Lijun
    Guo, Chunyan
    Yan, Liting
    Li, Huijin
    Sun, Jingying
    Huo, Xueping
    Xie, Xin
    Hu, Jun
    MOLECULAR MEDICINE REPORTS, 2020, 22 (02) : 733 - 738
  • [26] ανβ3 integrin-mediated activation of p38 MAPK in human cholangiocarcinoma
    Yamagiwa, Y
    Marienfeld, C
    Patel, T
    GASTROENTEROLOGY, 2003, 124 (04) : A729 - A729
  • [27] Increased expression of S100A6 promotes cell proliferation in gastric cancer cells
    Wang, Xiao-Hong
    Du, Hong
    Li, Lin
    Shao, Duan-Fang
    Zhong, Xi-Yao
    Hu, Ying
    Liu, Yi-Qiang
    Xing, Xiao-Fang
    Cheng, Xiao-Jing
    Guo, Ting
    Li, Shen
    Li, Zi-Yu
    Bu, Zhao-De
    Wen, Xian-Zi
    Zhang, Lian-Hai
    Ji, Jia-Fu
    ONCOLOGY LETTERS, 2017, 13 (01) : 222 - 230
  • [28] Activation of HuR downstream of p38 MAPK promotes cardiomyocyte hypertrophy
    Slone, Samuel
    Anthony, Sarah R.
    Wu, Xiaoqing
    Benoit, Joshua B.
    Aube, Jeffrey
    Xu, Liang
    Tranter, Michael
    CELLULAR SIGNALLING, 2016, 28 (11) : 1735 - 1741
  • [29] Activation of spinal PDGFRβ in microglia promotes neuronal autophagy via p38 MAPK pathway in morphine-tolerant rats
    Jia, Xiaoqian
    Zhang, Anqi
    Li, Zheng
    Peng, Xiaoling
    Tian, Xuebi
    Gao, Feng
    JOURNAL OF NEUROCHEMISTRY, 2021, 158 (02) : 373 - 390
  • [30] Interlukin-17A Promotes Aortic Endothelial Activation Via Transcriptionally and Post Transcriptionally Activating p38 MAPK Pathway
    Mai, Jietang
    Nanayakkara, Gayani
    Lopez-Pastrana, Jahaira
    Li, Xinyuan
    Li, Ya-Feng
    Wang, Xin
    Virtue, Anthony
    Shao, Ying
    Shan, Huimin
    Liu, Fang
    Autieri, Michael
    Iwakura, Yoichiro
    Jiang, Xiaohua
    Wang, Hong
    Yang, Xiao-Feng
    FASEB JOURNAL, 2016, 30
12345