Protective effects of vitamins C and E against hepatotoxicity induced by methyl parathion in rats

被引：39

作者：

Uzunhisarcikli, Meltem ^{[1
]}

Kalender, Yusuf ^{[2
]}

机构：

[1] Gazi Univ, Vocat High Sch, Hlth Serv, TR-06830 Ankara, Turkey

[2] Gazi Univ, Fac Arts & Sci, Dept Biol, TR-06500 Ankara, Turkey

来源：

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY | 2011年 / 74卷 / 07期

关键词：

Organophosphate insecticide; Methyl parathion; Hepatotoxicity; Electron microscopy; Vitamin C; Vitamin E; FREE-RADICAL METABOLISM; INDUCED CARDIOTOXICITY; BIOCHEMICAL INDEXES; ORGANOPHOSPHORUS; TOXICITY; DIAZINON; LIVER; INSECTICIDE; EXPOSURE; HEALTH;

D O I：

10.1016/j.ecoenv.2011.07.001

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Male rats were given vitamins C+E, methyl parathion, or both daily via gavage for seven weeks. Body weight was decreased while liver weight increased significantly at the end of fourth and seventh weeks in the methyl parathion- and methyl parathion plus vitamin-treated groups. Serum total protein, albumin, triglyceride, low density lipoprotein-cholesterol (VLDL-cholesterol) levels decreased, and serum alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl-transferase (GGT), lactate dehydrogenase (LDH), and total cholesterol levels increased significantly in the methyl parathion- and the methyl parathion plus vitamin-treated rats. There was a statistically significant difference for all biochemical parameters when the methyl parathion plus vitamin-treated group was compared with methyl parathion-treated group. In electron microscopic investigation, cytopathological alterations were observed in hepatocytes of the methyl parathion- and the methyl parathion plus vitamin-treated rats. As a result, methyl parathion-induced hepatotoxicity is reduced by vitamins C+E, but vitamins C+E did not provide complete protection. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：2112 / 2118

页数：7

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