Tendon injuries: basic science and new repair proposals

被引：173
作者：
Wu, Fan [1 ]
Nerlich, Michael [2 ]
Docheva, Denitsa [3 ,4 ]
机构：
[1] LMU, Dept Surg, Expt Surg & Regenerat Med, Munich, Germany
[2] Univ Regensburg, Med Ctr, Dept Trauma Surg, Regensburg, Germany
[3] Univ Regensburg, Med Ctr, Dept Trauma Surg, Expt Trauma Surg, Franz Josef Strauss Allee 11, D-93053 Regensburg, Germany
[4] Med Univ Plovdiv, Dept Med Biol, Plovdiv, Bulgaria
来源：
EFORT OPEN REVIEWS | 2017年 / 2卷 / 07期
关键词：
tendon repair; cell-based therapy; tendon stem/progenitor cells; mesenchymal stem cells; growth factors; biomaterials; MESENCHYMAL STEM-CELLS; PLATELET-RICH PLASMA; ROTATOR CUFF REPAIR; MARROW STROMAL CELLS; AGE-RELATED-CHANGES; ACHILLES-TENDON; GROWTH-FACTOR; IN-VIVO; QUANTITATIVE ASSESSMENT; STEM/PROGENITOR CELLS;
D O I：
10.1302/2058-5241.2.160075
中图分类号：
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];
学科分类号：
摘要：
Tendons connect muscles to bones, ensuring joint movement. With advanced age, tendons become more prone to degeneration followed by injuries. Tendon repair often requires lengthy periods of rehabilitation, especially in elderly patients. Existing medical and surgical treatments often fail to regain full tendon function. The development of novel treatment methods has been hampered due to limited understanding of basic tendon biology. Recently, it was discovered that tendons, similar to other mesenchymal tissues, contain tendon stem/progenitor cells (TSPCs) which possess the common stem cell properties. The current strategies for enhancing tendon repair consist mainly of applying stem cells, growth factors, natural and artificial biomaterials alone or in combination. In this review, we summarise the basic biology of tendon tissues and provide an update on the latest repair proposals for tendon tears.
引用
收藏
页码：332 / 342
页数：11
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