Bleeding related to disturbed fibrinolysis

被引：81
作者：
Kolev, Krasimir [1 ]
Longstaff, Colin [2 ]
机构：
[1] Semmelweis Univ, Dept Med Biochem, Budapest, Hungary
[2] Natl Inst Biol Stand & Controls, Biotherapeut Grp, S Mimms EN6 3QG, Herts, England
来源：
BRITISH JOURNAL OF HAEMATOLOGY | 2016年 / 175卷 / 01期
基金：
匈牙利科学研究基金会;
关键词：
fibrinolysis; acute promyelocytic leukaemia; antiplasmin; bleeding disorders; plasminogen activator inhibitor type 1; THROMBIN-ACTIVATABLE FIBRINOLYSIS; TISSUE-PLASMINOGEN ACTIVATOR; DISSEMINATED INTRAVASCULAR COAGULATION; ACUTE PROMYELOCYTIC LEUKEMIA; TRANEXAMIC ACID; FACTOR-XIII; CLOT STRUCTURE; HEMOPHILIA-A; FACTOR-VIII; INHERITED DEFICIENCY;
D O I：
10.1111/bjh.14255
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The components and reactions of the fibrinolysis system are well understood. The pathway has fewer reactants and interactions than coagulation, but the generation of a complete quantitative model is complicated by the need to work at the solid-liquid interface of fibrin. Diagnostic tools to detect disease states due to malfunctions in the fibrinolysis pathway are also not so well developed as is the case with coagulation. However, there are clearly a number of inherited or acquired pathologies where hyperfibrinolysis is a serious, potentially life-threatening problem and a number of antifibrinolytc drugs are available to treat hyperfibrinolysis. These topics will be covered in the following review.
引用
收藏
页码：12 / 23
页数：12
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