Desorption electrospray ionization mass spectrometry for lipid characterization and biological tissue imaging

被引：209

作者：

Eberlin, Livia S.

Ferreira, Christina R.

Dill, Allison L.

Ifa, Demian R.

Cooks, R. Graham ^{[1
]}

机构：

[1] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS | 2011年 / 1811卷 / 11期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

Ambient mass spectrometry; Imaging; Lipidomics; Disease diagnosis; Desorption electrospray ionization; Lipid characterization; FATTY-ACID COMPOSITIONS; CHOLESTEROL SULFATE; INFILTRATING LESIONS; PARTIAL SEPARATION; PHOSPHOLIPIDS; CANCER; BRAIN; DESI; PROFILES; CELLS;

D O I：

10.1016/j.bbalip.2011.05.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Desorption electrospray ionization mass spectrometry (DESI-MS) imaging of biological samples allows untargeted analysis and structural characterization of lipids ionized from the near-surface region of a sample under ambient conditions. DESI is a powerful and sensitive MS ionization method for 2D and 3D imaging of lipids from direct and unmodified complex biological samples. This review describes the strengths and limitations of DESI-MS for lipid characterization and imaging together with the technical workflow and a survey of applications. Included are discussions of lipid mapping and biomarker discovery as well as a perspective on the future of DESI imaging. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：946 / 960

页数：15

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