Desorption electrospray ionization mass spectrometry for lipid characterization and biological tissue imaging

被引：209
|
作者：
Eberlin, Livia S.
Ferreira, Christina R.
Dill, Allison L.
Ifa, Demian R.
Cooks, R. Graham [1 ]
机构：
[1] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS | 2011年 / 1811卷 / 11期
基金：
美国国家卫生研究院; 美国国家科学基金会;
关键词：
Ambient mass spectrometry; Imaging; Lipidomics; Disease diagnosis; Desorption electrospray ionization; Lipid characterization; FATTY-ACID COMPOSITIONS; CHOLESTEROL SULFATE; INFILTRATING LESIONS; PARTIAL SEPARATION; PHOSPHOLIPIDS; CANCER; BRAIN; DESI; PROFILES; CELLS;
D O I：
10.1016/j.bbalip.2011.05.006
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Desorption electrospray ionization mass spectrometry (DESI-MS) imaging of biological samples allows untargeted analysis and structural characterization of lipids ionized from the near-surface region of a sample under ambient conditions. DESI is a powerful and sensitive MS ionization method for 2D and 3D imaging of lipids from direct and unmodified complex biological samples. This review describes the strengths and limitations of DESI-MS for lipid characterization and imaging together with the technical workflow and a survey of applications. Included are discussions of lipid mapping and biomarker discovery as well as a perspective on the future of DESI imaging. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码：946 / 960
页数：15
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