A Walking Intervention Among Men With Prostate Cancer: A Pilot Study

被引:21
|
作者
Pernar, Claire H. [1 ]
Fall, Katja [2 ]
Rider, Jennifer R. [3 ]
Markt, Sarah C. [1 ]
Adami, Hans-Olov [1 ,4 ]
Andersson, Sven-Olof [5 ]
Valdimarsdottir, Unnur [1 ,4 ,6 ]
Andren, Ove [5 ]
Mucci, Lorelei A. [1 ]
机构
[1] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA
[2] Orebro Univ, Sch Hlth & Med Sci, Dept Clin Epidemiol & Biostat, Orebro, Sweden
[3] Boston Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA USA
[4] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden
[5] Orebro Univ, Sch Hlth & Med Sci, Dept Urol, Orebro, Sweden
[6] Univ Iceland, Ctr Publ Hlth Sci, Reykjavik, Iceland
基金
美国国家卫生研究院;
关键词
Biomarkers; Cardiovascular health; Exercise; Quality of life; Randomized trial; RANDOMIZED CONTROLLED-TRIAL; QUALITY-OF-LIFE; ANDROGEN SUPPRESSION THERAPY; PHYSICAL-ACTIVITY; RADICAL PROSTATECTOMY; AEROBIC EXERCISE; DEPRIVATION THERAPY; DIAGNOSIS; RESISTANCE; SURVIVORS;
D O I
10.1016/j.clgc.2017.05.022
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Men diagnosed with prostate cancer have increased risk of disease progression, cardiovascular events, and quality of life impairments. Men with a recent diagnosis randomly assigned to a walking group intervention maintained 10,000 steps per day and experienced improvement in cardiovascular biomarkers compared with usual care. A larger walking group intervention is needed to investigate its potential for improvement in longterm outcomes. Background: Men diagnosed with prostate cancer have increased risk for disease progression, cardiovascular events, and impairments in quality of life. This pilot study evaluated the feasibility of a randomized walking group intervention to improve quality of life, circulating biomarkers, and morbidity among men with newly diagnosed prostate cancer. Methods: Men were recruited at rebro University Hospital, Sweden, and randomized to an 11-week walking group intervention (n = 21) or usual care (n = 20). The intervention included weekly 1-hour walking group sessions and maintenance of 10,000 steps/day. Outcomes were changes in body composition, clinical factors, biomarkers of cardiovascular health, and quality of life between baseline and end of study. Analysis of covariance was used to compare outcomes in each group adjusted for baseline values. Results: All 41 men randomized completed the 11week trial. Men assigned to the intervention walked on average 10,644 steps/day, and 92% reported missing 2 or fewer sessions. Both groups experienced similar weight loss at 11 weeks. Men in the intervention had a significant adjusted mean change in high-density lipoprotein of 0.14 mmol/L (95% confidence interval [CI], 0.01-0.27; P =.04), and suggestive adjusted mean changes in low-density lipoprotein of = 0.22 mmol/L (95% CI, = 0.47 to 0.03; P =.08) and in systolic blood pressure of = 8.5 mm Hg (95% CI, = 21.2 to 4.2; P =.18), compared with the usual care group. Conclusions: A walking group intervention among men with recent diagnosis of prostate cancer is feasible and potentially effective in improving cardiovascular health. A larger randomized trial of longer duration is required to elucidate its potential for improvement in longer term outcomes. (C) 2017 Elsevier Inc. All rights reserved.
引用
收藏
页码:E1021 / E1028
页数:8
相关论文
共 50 条
  • [31] The men's eating and living (MEAL) study: A multi-center pilot trial of dietary intervention for the treatment of prostate cancer.
    Parsons, J. Kellogg
    Newman, Vick
    Mohler, James L.
    Pierce, John P.
    Paskett, Electra
    Marshall, James
    JOURNAL OF UROLOGY, 2007, 177 (04): : 96 - 97
  • [32] A PILOT STUDY TO COMPARE A COMMUNITY HEALTH WORKER-LED VS A PHYSICIAN-LED INTERVENTION FOR PROSTATE CANCER SCREENING DECISION-MAKING AMONG BLACK MEN
    Martinez-Lopez, Natalia
    Makarov, Danil V.
    Ciprut, Shannon
    Hickman, Theodore
    Cole, Helen
    Feuer, Zachary
    Fenstermaker, Michael
    Gold, Heather
    Loeb, Stacy
    Ravenell, Joseph E.
    JOURNAL OF UROLOGY, 2020, 203 : E1100 - E1101
  • [33] Effects of a Dog Walking Intervention on a University Campus: A Pilot Study
    Sartore-Baldwin, Melanie
    Baker, Jaclyn
    Schwab, Lacey
    Crenshaw, John
    D'Amico, Maria
    Das, Bhibha
    Mahar, Matthew
    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 2017, 49 (05): : 33 - 33
  • [34] Prostate cancer increasing among young men
    不详
    EUROPEAN JOURNAL OF CANCER, 1999, 35 (07) : 1040 - 1040
  • [35] Supplement use among men with prostate cancer
    Wiygul, JB
    Evans, BR
    Peterson, BL
    Polascik, TJ
    Walther, PJ
    Robertson, CN
    Albala, DM
    Demark-Wahnefried, W
    UROLOGY, 2005, 66 (01) : 161 - 166
  • [36] Prostate Cancer Among Black Men in Canada
    Albers, Patrick
    Bashir, Safaa
    Mookerji, Nikhile
    Broomfield, Stacey
    Martin, Anais Medina
    Ghosh, Sunita
    Kinnaird, Adam
    JAMA NETWORK OPEN, 2024, 7 (06) : e2418475
  • [37] Outcomes of a pilot study exploring the role of digital health coaching for men with prostate cancer
    Handley, Nathan
    Wen, Kuang-Yi
    Gomaa, Sameh
    Shimada, Ayako
    Leiby, Benjamin
    Brassil, Kelly Jean
    Jackson, Lindsey
    Calvaresi, Anne
    Dicker, Adam P.
    JOURNAL OF CLINICAL ONCOLOGY, 2021, 39 (28)
  • [38] Use of complementary and alternative medicine in men with family history of prostate cancer: A pilot study
    Beebe-Dimmer, JL
    Wood, DP
    Gruber, SB
    Douglas, JA
    Bonner, JD
    Mohai, C
    Zuhlke, KA
    Shepherd, C
    Cooney, KA
    UROLOGY, 2004, 63 (02) : 282 - 287
  • [39] Targeted Next-Generation Sequencing in Men with Metastatic Prostate Cancer: a Pilot Study
    Barata, Pedro C.
    Mendiratta, Prateek
    Heald, Brandie
    Klek, Stefan
    Grivas, Petros
    Sohal, Davendra P. S.
    Garcia, Jorge A.
    TARGETED ONCOLOGY, 2018, 13 (04) : 495 - 500
  • [40] The information-seeking behaviours of partners of men with prostate cancer: a qualitative pilot study
    Feltwell, AK
    Rees, CE
    PATIENT EDUCATION AND COUNSELING, 2004, 54 (02) : 179 - 185