Chemo-preventive and therapeutic effect of the dietary flavonoid kaempferol: A comprehensive review

被引：304
作者：
Imran, Muhammad [1 ]
Rauf, Abdur [2 ]
Shah, Zafar Ali [2 ]
Saeed, Farhan [3 ]
Imran, Ali [3 ]
Arshad, Muhammad Umair [3 ]
Ahmad, Bashir [4 ]
Bawazeer, Sami [5 ]
Atif, Muhammad [6 ]
Peters, Dennis G. [7 ]
Mubarak, Mohammad S. [8 ]
机构：
[1] Univ Lahore, Fac Allied & Hlth Sci, Univ Inst Diet & Nutr Sci, Lahore, Pakistan
[2] Univ Swabi Anbar, Dept Chem, Swabi 23430, Kpk, Pakistan
[3] Govt Coll Univ, Fac Home & Food Sci, Faisalabad, Pakistan
[4] Univ Peshawar, Ctr Biotechnol & Microbiol, Peshawar, Pakistan
[5] Umm Al Qura Univ, Coll Publ Hlth & Hlth Informat, Dept EMS Paramed, Mecca, Saudi Arabia
[6] Jouf Univ, Dept Clin Lab Sci, Coll Appl Med Sci, Sakaka, Saudi Arabia
[7] Indiana Univ, Dept Chem, Bloomington, IN USA
[8] Univ Jordan, Dept Chem, Amman 11942, Jordan
来源：
PHYTOTHERAPY RESEARCH | 2019年 / 33卷 / 02期
关键词：
anticancer; antidiabetic; cardioprotective; kaempferol; mechanisms of action; oxidative stress; TO-MESENCHYMAL TRANSITION; OXIDATIVE STRESS; COMPOUND KAEMPFEROL; EPITHELIAL-CELLS; DOWN-REGULATION; MOUSE MODEL; IN-VITRO; KAPPA-B; CANCER; PROTECTS;
D O I：
10.1002/ptr.6227
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Kaempferol, a natural flavonoid present in several plants, possesses a wide range of therapeutic properties such as antioxidant, anticancer, and anti-inflammatory. It has a significant role in reducing cancer and can act as a therapeutic agent in the treatment of diseases and ailments such as diabetes, obesity, cardiovascular diseases, oxidative stress, asthma, and microbial contamination disorders. Kaempferol acts through different mechanisms: It induces apoptosis (HeLa cervical cancer cells), decreases cell viability (G2/M phase), downregulates phosphoinositide 3-kinase (PI3K)/AKT (protein kinase B) and human T-cell leukemia/lymphoma virus-I (HTLV-I) signaling pathways, suppresses protein expression of epithelial-mesenchymal transition (EMT)-related markers including N-cadherin, E-cadherin, Slug, and Snail, and metastasis-related markers such as matrix metallopeptidase 2 (MMP-2). Accordingly, the aim of the present review is to collect information pertaining to the effective role of kaempferol against various degenerative disorders, summarize the antioxidant, anti-inflammatory, anticancer, antidiabetic, and antiaging effects of kaempferol and to review the progress of recent research and available data on kaempferol as a protective and chemotherapeutic agent against several ailments.
引用
收藏
页码：263 / 275
页数：13
相关论文
共 100 条
[21]   Dietary Flavonoid and Lignan Intake and Mortality in Prospective Cohort Studies: Systematic Review and Dose-Response Meta-Analysis [J].
Grosso, Giuseppe ;
Micek, Agnieszka ;
Godos, Justyna ;
Pajak, Andrzej ;
Sciacca, Salvatore ;
Galvano, Fabio ;
Giovannucci, Edward L. .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 2017, 185 (12) :1304-1316
[22]   A comprehensive meta-analysis on dietary flavonoid and lignan intake and cancer risk: Level of evidence and limitations [J].
Grosso, Giuseppe ;
Godos, Justyna ;
Lamuela-Raventos, Rosa ;
Ray, Sumantra ;
Micek, Agnieszka ;
Pajak, Andrzej ;
Sciacca, Salvatore ;
D'Orazio, Nicolantonio ;
Del Rio, Daniele ;
Galvano, Fabio .
MOLECULAR NUTRITION & FOOD RESEARCH, 2017, 61 (04)
[23]   Kaempferol protects cardiomyocytes against anoxiaireoxygenation injury via mitochondrial pathway mediated by SIRT1 [J].
Guo, Zhen ;
Liao, Zhangping ;
Huang, Liqing ;
Liu, Dan ;
Yin, Dong ;
He, Ming .
EUROPEAN JOURNAL OF PHARMACOLOGY, 2015, 761 :245-253
[24]  
Gupta GK, 2013, NANOMEDICINE-UK, V8, P757, DOI [10.2217/nnm.12.171, 10.2217/NNM.12.171]
[25]  
Haidari F, 2011, IRAN J PHARM RES, V10, P811
[26]   Induction of caspase cascade pathway by kaempferol-3-O-rhamnoside in LNCaP prostate cancer cell lines [J].
Halimah, Eli ;
Diantini, Ajeng ;
Destiani, Dika P. ;
Pradipta, Ivan S. ;
Sastramihardja, Herri S. ;
Lestari, Keri ;
Subarnas, Anas ;
Abdulah, Rizky ;
Koyama, Hiroshi .
BIOMEDICAL REPORTS, 2015, 3 (01) :115-117
[27]   Flavonoids as peroxynitrite scavengers: the role of the hydroxyl groups [J].
Heijnen, CGM ;
Haenen, GRMM ;
van Acker, FAA ;
van der Vijgh, WJF ;
Bast, A .
TOXICOLOGY IN VITRO, 2001, 15 (01) :3-6
[28]   Flavonoid antioxidants: chemistry, metabolism and structure-activity relationships [J].
Heim, KE ;
Tagliaferro, AR ;
Bobilya, DJ .
JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2002, 13 (10) :572-584
[29]   Flavonoids, flavonoid-rich foods, and cardiovascular risk: a meta-analysis of randomized controlled trials [J].
Hooper, Lee ;
Kroon, Paul A. ;
Rimm, Eric B. ;
Cohn, Jeffrey S. ;
Harvey, Ian ;
Le Cornu, Kathryn A. ;
Ryder, Jonathan J. ;
Hall, Wendy L. ;
Cassidy, Aedin .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 2008, 88 (01) :38-50
[30]   Kaempferol induces autophagy through AMPK and AKT signaling molecules and causes G2/M arrest via downregulation of CDK1/cyclin B in SK-HEP-1 human hepatic cancer cells [J].
Huang, Wen-Wen ;
Tsai, Shih-Chang ;
Peng, Shu-Fen ;
Lin, Meng-Wei ;
Chiang, Jo-Hua ;
Chiu, Yu-Jen ;
Fushiya, Shinji ;
Tseng, Michael T. ;
Yang, Jai-Sing .
INTERNATIONAL JOURNAL OF ONCOLOGY, 2013, 42 (06) :2069-2077
12345678910