Chemo-preventive and therapeutic effect of the dietary flavonoid kaempferol: A comprehensive review

被引：304
作者：
Imran, Muhammad [1 ]
Rauf, Abdur [2 ]
Shah, Zafar Ali [2 ]
Saeed, Farhan [3 ]
Imran, Ali [3 ]
Arshad, Muhammad Umair [3 ]
Ahmad, Bashir [4 ]
Bawazeer, Sami [5 ]
Atif, Muhammad [6 ]
Peters, Dennis G. [7 ]
Mubarak, Mohammad S. [8 ]
机构：
[1] Univ Lahore, Fac Allied & Hlth Sci, Univ Inst Diet & Nutr Sci, Lahore, Pakistan
[2] Univ Swabi Anbar, Dept Chem, Swabi 23430, Kpk, Pakistan
[3] Govt Coll Univ, Fac Home & Food Sci, Faisalabad, Pakistan
[4] Univ Peshawar, Ctr Biotechnol & Microbiol, Peshawar, Pakistan
[5] Umm Al Qura Univ, Coll Publ Hlth & Hlth Informat, Dept EMS Paramed, Mecca, Saudi Arabia
[6] Jouf Univ, Dept Clin Lab Sci, Coll Appl Med Sci, Sakaka, Saudi Arabia
[7] Indiana Univ, Dept Chem, Bloomington, IN USA
[8] Univ Jordan, Dept Chem, Amman 11942, Jordan
来源：
PHYTOTHERAPY RESEARCH | 2019年 / 33卷 / 02期
关键词：
anticancer; antidiabetic; cardioprotective; kaempferol; mechanisms of action; oxidative stress; TO-MESENCHYMAL TRANSITION; OXIDATIVE STRESS; COMPOUND KAEMPFEROL; EPITHELIAL-CELLS; DOWN-REGULATION; MOUSE MODEL; IN-VITRO; KAPPA-B; CANCER; PROTECTS;
D O I：
10.1002/ptr.6227
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Kaempferol, a natural flavonoid present in several plants, possesses a wide range of therapeutic properties such as antioxidant, anticancer, and anti-inflammatory. It has a significant role in reducing cancer and can act as a therapeutic agent in the treatment of diseases and ailments such as diabetes, obesity, cardiovascular diseases, oxidative stress, asthma, and microbial contamination disorders. Kaempferol acts through different mechanisms: It induces apoptosis (HeLa cervical cancer cells), decreases cell viability (G2/M phase), downregulates phosphoinositide 3-kinase (PI3K)/AKT (protein kinase B) and human T-cell leukemia/lymphoma virus-I (HTLV-I) signaling pathways, suppresses protein expression of epithelial-mesenchymal transition (EMT)-related markers including N-cadherin, E-cadherin, Slug, and Snail, and metastasis-related markers such as matrix metallopeptidase 2 (MMP-2). Accordingly, the aim of the present review is to collect information pertaining to the effective role of kaempferol against various degenerative disorders, summarize the antioxidant, anti-inflammatory, anticancer, antidiabetic, and antiaging effects of kaempferol and to review the progress of recent research and available data on kaempferol as a protective and chemotherapeutic agent against several ailments.
引用
收藏
页码：263 / 275
页数：13
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