The Role of Deubiquitinases in Vascular Diseases

被引：16
作者：
Wang, Biqing [1 ,2 ]
Cai, Wenbin [1 ,2 ]
Ai, Ding [1 ,2 ]
Zhang, Xu [1 ,2 ]
Yao, Liu [1 ,2 ]
机构：
[1] Tianjin Med Univ, Key Lab Immune Microenvironm & Dis, Minist Educ, Tianjin 300070, Peoples R China
[2] Tianjin Med Univ, Dept Physiol & Pathophysiol, Tianjin Key Lab Metab Dis, Tianjin 300070, Peoples R China
来源：
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH | 2020年 / 13卷 / 02期
基金：
中国国家自然科学基金;
关键词：
Deubiquitinases; Atherosclerosis; Angiogenesis; Abdominal Aortic Aneurysm; Hypertension; NF-KAPPA-B; UBIQUITIN-PROTEASOME SYSTEM; PROTEIN-INDUCED PROTEIN-1; ENDOTHELIAL-CELLS; A20; PROTECTS; NLRP3; INFLAMMASOME; OXIDATIVE STRESS; CHANNEL ENAC; ACTIVATION; APOPTOSIS;
D O I：
10.1007/s12265-019-09909-x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Deubiquitinases (DUBs) are a major component of the ubiquitin-proteasome system in eukaryotic cells; the system plays a crucial role in many biological processes, such as inflammation, oxidative stress, and cell apoptosis, which are important in vascular biology and pathology. DUBs have drawn significant attention in recent years, and their function is increasingly linked with vascular diseases. In this review, we summarize the indirect and direct evidence for the effects of DUBs on atherosclerosis, abdominal aortic aneurysm, angiogenesis, and hypertension, and point out pathways that could be pursued for investigating DUBs. Intervention in the function of DUBs in vascular diseases has potential therapeutic value.
引用
收藏
页码：131 / 141
页数：11
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