The ideal temporary implant should offer enough mechanical support to allow healing of the fracture and then biodegrade and be resorbed by metabolic mechanisms without causing any toxic effect. The aim of this research has been to simultaneously study in situ bone healing and the biodegradation of AZ31 Mg alloy as an osteosynthesis material. The in vivo study was carried out in AZ31 implants with and without Mg-fluoride coating inserted in un-fractured and fractured femurs of Wistar rats for long experimentation time, from 1 to 13 months, by means of computed tomography, histological and histomorphometric analysis. Tomography analysis showed the bone healing and biodegradation of AZ31 implants. The fracture is healed in 100% of the animals, and AZ31 maintains its mechanical integrity throughout the healing process. Biodegradation was monitored, quantifying the evolution of gas over time by 3D composition of tomography images. In all the studied groups, gas pockets disappear with time as a result of the diffusion process through soft tissues. Histomorphometric studies reveal that after 13 months the 46.32% of AZ31 alloy has been resorbed. The resorption of the coated and uncoated AZ31 implants inserted in fractured femurs after 1, 9 and 13 months does not have statistically significant differences. There is a balance between the biodegradation of AZ31 and bone healing which allows the use of AZ31 to be proposed as an osteosynthesis material.
机构:
Chonbuk Natl Univ, Coll Engn, Dept Bionano Syst Engn, Jeonju 561756, South Korea
Chonbuk Natl Univ, Adv Wind Power Syst Res Inst, Dept Mech Design Engn, Jeonju 561756, South KoreaChonbuk Natl Univ, Coll Engn, Dept Bionano Syst Engn, Jeonju 561756, South Korea
Abdal-hay, Abdalla
;
Barakat, Nasser A. M.
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Chonbuk Natl Univ, Organ Mat & Fiber Engn Dept, Jeonju 561756, South Korea
Menia Univ, Dept Chem Engn, El Minia, EgyptChonbuk Natl Univ, Coll Engn, Dept Bionano Syst Engn, Jeonju 561756, South Korea
Barakat, Nasser A. M.
;
Lim, Jae Kyoo
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Chonbuk Natl Univ, Adv Wind Power Syst Res Inst, Dept Mech Design Engn, Jeonju 561756, South KoreaChonbuk Natl Univ, Coll Engn, Dept Bionano Syst Engn, Jeonju 561756, South Korea
机构:
CSIC, CENIM, Madrid 28040, SpainCSIC, CENIM, Madrid 28040, Spain
Alvarez-Lopez, M.
;
Dolores Pereda, Maria
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Univ Nacl La Plata CONICET, Fac Ciencias Exactas, INIFTA, RA-1900 La Plata, Buenos Aires, Argentina
Univ Nacl La Plata, Fac Ingn, RA-1900 La Plata, Buenos Aires, ArgentinaCSIC, CENIM, Madrid 28040, Spain
Dolores Pereda, Maria
;
del Valle, J. A.
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CSIC, CENIM, Madrid 28040, SpainCSIC, CENIM, Madrid 28040, Spain
del Valle, J. A.
;
Fernandez-Lorenzo, M.
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Univ Nacl La Plata CONICET, Fac Ciencias Exactas, INIFTA, RA-1900 La Plata, Buenos Aires, Argentina
Univ Nacl La Plata, Fac Ingn, RA-1900 La Plata, Buenos Aires, ArgentinaCSIC, CENIM, Madrid 28040, Spain
Fernandez-Lorenzo, M.
;
Garcia-Alonso, M. C.
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CSIC, CENIM, Madrid 28040, SpainCSIC, CENIM, Madrid 28040, Spain
Garcia-Alonso, M. C.
;
Ruano, O. A.
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机构:
CSIC, CENIM, Madrid 28040, SpainCSIC, CENIM, Madrid 28040, Spain
Ruano, O. A.
;
Escudero, M. L.
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h-index: 0
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CSIC, CENIM, Madrid 28040, SpainCSIC, CENIM, Madrid 28040, Spain
机构:
Chonbuk Natl Univ, Coll Engn, Dept Bionano Syst Engn, Jeonju 561756, South Korea
Chonbuk Natl Univ, Adv Wind Power Syst Res Inst, Dept Mech Design Engn, Jeonju 561756, South KoreaChonbuk Natl Univ, Coll Engn, Dept Bionano Syst Engn, Jeonju 561756, South Korea
Abdal-hay, Abdalla
;
Barakat, Nasser A. M.
论文数: 0引用数: 0
h-index: 0
机构:
Chonbuk Natl Univ, Organ Mat & Fiber Engn Dept, Jeonju 561756, South Korea
Menia Univ, Dept Chem Engn, El Minia, EgyptChonbuk Natl Univ, Coll Engn, Dept Bionano Syst Engn, Jeonju 561756, South Korea
Barakat, Nasser A. M.
;
Lim, Jae Kyoo
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h-index: 0
机构:
Chonbuk Natl Univ, Adv Wind Power Syst Res Inst, Dept Mech Design Engn, Jeonju 561756, South KoreaChonbuk Natl Univ, Coll Engn, Dept Bionano Syst Engn, Jeonju 561756, South Korea
机构:
CSIC, CENIM, Madrid 28040, SpainCSIC, CENIM, Madrid 28040, Spain
Alvarez-Lopez, M.
;
Dolores Pereda, Maria
论文数: 0引用数: 0
h-index: 0
机构:
Univ Nacl La Plata CONICET, Fac Ciencias Exactas, INIFTA, RA-1900 La Plata, Buenos Aires, Argentina
Univ Nacl La Plata, Fac Ingn, RA-1900 La Plata, Buenos Aires, ArgentinaCSIC, CENIM, Madrid 28040, Spain
Dolores Pereda, Maria
;
del Valle, J. A.
论文数: 0引用数: 0
h-index: 0
机构:
CSIC, CENIM, Madrid 28040, SpainCSIC, CENIM, Madrid 28040, Spain
del Valle, J. A.
;
Fernandez-Lorenzo, M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Nacl La Plata CONICET, Fac Ciencias Exactas, INIFTA, RA-1900 La Plata, Buenos Aires, Argentina
Univ Nacl La Plata, Fac Ingn, RA-1900 La Plata, Buenos Aires, ArgentinaCSIC, CENIM, Madrid 28040, Spain
Fernandez-Lorenzo, M.
;
Garcia-Alonso, M. C.
论文数: 0引用数: 0
h-index: 0
机构:
CSIC, CENIM, Madrid 28040, SpainCSIC, CENIM, Madrid 28040, Spain
Garcia-Alonso, M. C.
;
Ruano, O. A.
论文数: 0引用数: 0
h-index: 0
机构:
CSIC, CENIM, Madrid 28040, SpainCSIC, CENIM, Madrid 28040, Spain
Ruano, O. A.
;
Escudero, M. L.
论文数: 0引用数: 0
h-index: 0
机构:
CSIC, CENIM, Madrid 28040, SpainCSIC, CENIM, Madrid 28040, Spain