Structures and spasmolytic activities of derivatives from sesquiterpenes of Alpinia speciosa and Alpinia japonica

被引：0
|
作者：
Morita, M [1 ]
Nakanishi, H [1 ]
Morita, H [1 ]
Mihashi, S [1 ]
Itokawa, H [1 ]
机构：
[1] TOKYO UNIV PHARM & LIFE SCI, DEPT PHARMACOGNOSY, HACHIOJI, TOKYO 19203, JAPAN
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 1996年 / 44卷 / 08期
关键词：
Alpinia speciosa; Alpinia japonica; sesquiterpene; spasmolytic activity;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Sesquiterpenes isolated from Alpinia speciosa and Alpinia japonica, and their derivatives were found to inhibit histamine- or barium chloride-induced contraction of excised guinea pig ileum when tested by the Magnus method, Major spasmolytic principles contained in those extracts were the sesquiterpenes, beta-eudesmol, nerolidol, humulene epoxide II and 4 alpha-hydroxydihydroagarofuran. Relationships between the chemical structures of the sesquiterpenes and their derivatives, and their spasmolytic activities were discussed.
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收藏
页码：1603 / 1606
页数：4
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