Alzheimer's disease and AP toxicity: from top to bottom

被引：331

作者：

Small, DH ^{[1
]}

Mok, SS

Bornstein, JC

机构：

[1] Univ Melbourne, Dept Pathol, Melbourne, Vic 3010, Australia

[2] Univ Melbourne, Dept Physiol, Melbourne, Vic 3010, Australia

来源：

NATURE REVIEWS NEUROSCIENCE | 2001年 / 2卷 / 08期

关键词：

D O I：

10.1038/35086072

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Evidence implicating the beta -amyloid protein (A beta) in the pathogenesis of Alzheimer's disease has steadily accumulated. However, the mechanism by which A beta causes dementia is unknown, Here we argue that a more integrated, top-down approach to brain function is needed to assess the role of A beta in Alzheimer's disease, and that more attention should be paid to the effects of A beta on synaptic function rather than on cell death.

引用

页码：595 / 598

页数：4

共 88 条

[1] Synaptic plasticity: taming the beast [J].

Abbott, L. F. ;

Nelson, Sacha B. .

NATURE NEUROSCIENCE, 2000, 3 (11) :1178-1183

[2] β-amyloid stimulation of inducible nitric-oxide synthase in astrocytes is interleukin-1β- and tumor necrosis factor-α (TNFα)-dependent, and involves a TNFα receptor-associated factor- and NFκB-inducing kinase-dependent signaling mechanism [J].

Akama, KT ;

Van Eldik, LJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (11) :7918-7924

[3] Amyloid β-peptide stimulates nitric oxide production in astrocytes through an NFκB-dependent mechanism [J].

Akama, KT ;

Albanese, C ;

Pestell, RG ;

Van Eldik, LJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (10) :5795-5800

[4] ASSOCIATIVE MEMORY NEURAL NETWORK WITH LOW TEMPORAL SPIKING RATES [J].

AMIT, DJ ;

TREVES, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (20) :7871-7875

[5]

ANDERSON AJ, 1995, J NEUROCHEM, V65, P1487

[6] Alzheimer's disease as a disorder of mechanisms underlying structural brain self-organization [J].

Arendt, T .

NEUROSCIENCE, 2001, 102 (04) :723-765

[7] MECHANISM FOR A SLIDING SYNAPTIC MODIFICATION THRESHOLD [J].

BEAR, MF .

NEURON, 1995, 15 (01) :1-4

[8] HYDROGEN-PEROXIDE MEDIATES AMYLOID-BETA PROTEIN TOXICITY [J].

BEHL, C ;

DAVIS, JB ;

LESLEY, R ;

SCHUBERT, D .

CELL, 1994, 77 (06) :817-827

[9] Effective neuronal learning with ineffective Hebbian learning rules [J].

Chechik, G ;

Meilijson, I ;

Ruppin, E .

NEURAL COMPUTATION, 2001, 13 (04) :817-840

[10] AN AMYLOID PEPTIDE, BETA-A4 25-35, MIMICS THE FUNCTION OF SUBSTANCE-P ON MODULATION OF NICOTINE-EVOKED SECRETION AND DESENSITIZATION IN CULTURED BOVINE ADRENAL CHROMAFFIN CELLS [J].

CHEUNG, NS ;

SMALL, DH ;

LIVETT, BG .

JOURNAL OF NEUROCHEMISTRY, 1993, 60 (03) :1163-1166

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