Positive regulatory effects of perioperative probiotic treatment on postoperative liver complications after colorectal liver metastases surgery: a double-center and double-blind randomized clinical trial

被引：90

作者：

Liu, Zhihua ^{[1
,2
]}

Li, Chao ^{[1
]}

Huang, Meijin ^{[1
]}

Tong, Chao ^{[1
]}

Zhang, Xingwei ^{[1
]}

Wang, Lei ^{[1
]}

Peng, Hui ^{[1
]}

Lan, Ping ^{[1
]}

Zhang, Peng ^{[2
]}

Huang, Nanqi ^{[1
]}

Peng, Junsheng ^{[1
]}

Wu, Xiaojian ^{[1
]}

Luo, Yanxing ^{[1
]}

Qin, Huanlong ^{[2
]}

Kang, Liang ^{[1
]}

Wang, Jianping ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Guangdong Gastrointestinal Hosp, Affiliated Hosp 6, Gastrointestinal Inst,Dept Colorectal Surg, Guangzhou 510655, Guangdong, Peoples R China

[2] Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Surg, Shanghai 200233, Peoples R China

来源：

BMC GASTROENTEROLOGY | 2015年 / 15卷

基金：

中国国家自然科学基金;

关键词：

Probiotics; Colorectal liver metastases; Zonulin; Postoperative complication; Liver barrier; PYLORUS-PRESERVING PANCREATICODUODENECTOMY; INFECTIOUS COMPLICATIONS; INTESTINAL PERMEABILITY; BARRIER FUNCTION; CANCER-PATIENTS; ZONULIN; SEPSIS; CELLS; EXPRESSION; SYNBIOTICS;

D O I：

10.1186/s12876-015-0260-z

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background: Colorectal liver metastases ( CLM) occur frequently and postoperative intestinal infection is a common complication. Our previous study showed that probiotics could decrease the rate of infectious complications after colectomy for colorectal cancer. To determine the effects of the perioperative administration of probiotics on serum zonulin levels which is a marker of intestinal permeability and the subsequent impact on postoperative infectious complications in patients with CLM. Methods: 150 patients with CLM were randomly divided into control group ( n = 68) and probiotics group ( n = 66). Probiotics and placebo were given orally for 6 days preoperatively and 10 days postoperatively to control group and probiotics group respectively. We used the local resection for metastatic tumor, while for large tumor, the segmental hepatectomy. Postoperative outcome were recorded. Furthermore, complications in patients with normal intestinal barrier function and the relation with serum zonulin were analyzed to evaluate the impact on the liver barrier dysfunction. Results: The incidence of infectious complications in the probiotics group was lower than control group. Analysis of CLM patients with normal postoperative intestinal barrier function paralleled with the serum zonulin level. And probiotics could also reduce the concentration of serum zonulin ( P = 0.004) and plasma endotoxin ( P < 0.001). Conclusion: Perioperative probiotics treatment could reduce the serum zonulin level, the rate of postoperative septicemia and maintain the liver barrier in patients undergoing CLM surgery. we propose a new model about the regulation of probiotics to liver barrier via clinical regulatory pathway. We recommend the preoperative oral intake of probiotics combined with postoperative continued probiotics treatment in patients who undergo CLM surgery.

引用

页数：13

共 39 条

[11]

JEMAL A, 2011, CA-CANCER J CLIN, V61, P69, DOI DOI 10.3322/CAAC.20107

[12] Synbiotics reduce postoperative infectious complications: a randomized controlled trial in biliary cancer patients undergoing hepatectomy [J].