Nidurufin as a new cell cycle inhibitor from marine-derived fungus Penicillium flavidorsum SHK1-27

被引：19
|
作者：
Ren, Hong [1 ]
Liu, Wei-wei [1 ]
机构：
[1] Beijing Technol & Business Univ, Coll Chem & Environm Engn, Beijing Key Lab Plant Resource Res & Dev, Beijing Higher Inst Engn Res Ctr Food Addit & Ing, Beijing 100048, Peoples R China
来源：
ARCHIVES OF PHARMACAL RESEARCH | 2011年 / 34卷 / 06期
关键词：
Penicillium flavidorsum SHK1-27; Nidurufin; Cytotoxicity; Cell cycle inhibitor; ASPERGILLUS-VERSICOLOR; ELUCIDATION;
D O I：
10.1007/s12272-011-0606-1
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A new cell cycle inhibitor, nidurufin (1), was isolated from the marine-derived fungus Penicillium flavidorsum SHK1-27. An evaluation of antitumor activity indicated that 1 induced in vitro cell cycle arrest at G(2)/M transition in the K562 cell line in a concentration and timedependent manner, with an IC(50) value of 12.6 M.
引用
收藏
页码：901 / 905
页数：5
相关论文
共 50 条
  • [41] A radical scavenging farnesylhydroquinone from a marine-derived fungus Penicillium sp.
    Son, BW
    Kim, JC
    Choi, HD
    Kang, JS
    ARCHIVES OF PHARMACAL RESEARCH, 2002, 25 (01) : 77 - 79
  • [42] Activated production of silent metabolites from marine-derived fungus Penicillium citrinum
    Gu, Yuqin
    Ding, Peiyu
    Liang, Zhipeng
    Song, Yan
    Liu, Yonghong
    Chen, Guangtong
    Li, Jian Lin
    FITOTERAPIA, 2018, 127 : 207 - 211
  • [43] Penicillivinacine, antimigratory diketopiperazine alkaloid from the marine-derived fungus Penicillium vinaceum
    Asiri, Ibrahim A. M.
    Badr, Jihan M.
    Youssef, Diaa T. A.
    PHYTOCHEMISTRY LETTERS, 2015, 13 : 53 - 58
  • [44] Citrinadin A, a novel pentacyclic alkaloid from marine-derived fungus Penicillium citrinum
    Tsuda, M
    Kasai, Y
    Komatsu, K
    Sone, T
    Tanaka, M
    Mikami, Y
    Kobayashi, J
    ORGANIC LETTERS, 2004, 6 (18) : 3087 - 3089
  • [45] Synthesis of triprenylated toluquinone and toluhydroquinone metabolites from a marine-derived Penicillium fungus
    Scheepers, Brent A.
    Klein, Rosalyn
    Davies-Coleman, Michael T.
    TETRAHEDRON LETTERS, 2006, 47 (47) : 8243 - 8246
  • [46] Cyclopentane-condensed Chromones from Marine-derived Fungus Penicillium oxalicum
    Bao, Jie
    Zhang, Xiao-Yong
    Dong, Jie-jie
    Xu, Xin-ya
    Nong, Xu-Hua
    Qi, Shu-Hua
    CHEMISTRY LETTERS, 2014, 43 (06) : 837 - 839
  • [47] Perinadine A, a novel tetracyclic alkaloid from marine-derived fungus Penicillium citrinum
    Sasaki, M
    Tsuda, M
    Sekiguchi, M
    Mikami, Y
    Kobayashi, J
    ORGANIC LETTERS, 2005, 7 (19) : 4261 - 4264
  • [48] Bioactive Indole Diterpenoids and Polyketides from the Marine-Derived Fungus Penicillium javanicum
    Zhao-Yang Liang
    Nan-Xing Shen
    Xiao-Jian Zhou
    Yao-Yao Zheng
    Min Chen
    Chang-Yun Wang
    Chemistry of Natural Compounds, 2020, 56 : 379 - 382
  • [49] A New Drimane Sesquiterpene Ester from the Marine-Derived Fungus Penicillium chrysogenum LD-201810
    Qingrong Huang
    Yanhua Wang
    Xiaoyan Chi
    Chong Liu
    Jianlong Zhang
    Chemistry of Natural Compounds, 2022, 58 : 1042 - 1044
  • [50] Penisporolides A and B, two new spiral lactones from the marine-derived fungus Penicillium sp.
    Li, Xiang
    Sattler, Isabel
    Lin, Wenhan
    JOURNAL OF ANTIBIOTICS, 2007, 60 (03): : 191 - 195
12345