Nidurufin as a new cell cycle inhibitor from marine-derived fungus Penicillium flavidorsum SHK1-27

被引：19
|
作者：
Ren, Hong [1 ]
Liu, Wei-wei [1 ]
机构：
[1] Beijing Technol & Business Univ, Coll Chem & Environm Engn, Beijing Key Lab Plant Resource Res & Dev, Beijing Higher Inst Engn Res Ctr Food Addit & Ing, Beijing 100048, Peoples R China
来源：
ARCHIVES OF PHARMACAL RESEARCH | 2011年 / 34卷 / 06期
关键词：
Penicillium flavidorsum SHK1-27; Nidurufin; Cytotoxicity; Cell cycle inhibitor; ASPERGILLUS-VERSICOLOR; ELUCIDATION;
D O I：
10.1007/s12272-011-0606-1
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A new cell cycle inhibitor, nidurufin (1), was isolated from the marine-derived fungus Penicillium flavidorsum SHK1-27. An evaluation of antitumor activity indicated that 1 induced in vitro cell cycle arrest at G(2)/M transition in the K562 cell line in a concentration and timedependent manner, with an IC(50) value of 12.6 M.
引用
收藏
页码：901 / 905
页数：5
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