Association study of dopamine D2, D3 receptor gene polymorphisms with motor fluctuations in PD

被引：74

作者：

Wang, J ^{[1
]}

Liu, ZL ^{[1
]}

Chen, B ^{[1
]}

机构：

[1] Sun Yat Sen Univ Med Sci, Affiliated Hosp 1, Dept Neurol, Guangzhou, Peoples R China

来源：

NEUROLOGY | 2001年 / 56卷 / 12期

关键词：

D O I：

10.1212/WNL.56.12.1757

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The authors investigated the association between dopamine receptor D2, D3 gene polymorphisms, and the risk of developing motor fluctuations in PD. DRD3 BalI and MspI polymorphisms, were not associated with risk of developing motor fluctuations. However, the genotypic distribution of DRD2 TaqIA polymorphism was significantly different in motor fluctuators and nonmotor fluctuators. These findings suggest that DRD2 TaqIA polymorphism may be associated with an increased risk for developing motor fluctuations in PD.

引用

页码：1757 / 1759

页数：3

共 11 条

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