The D-chiro-inositol paradox in the ovary

被引：99

作者：

Carlomagno, Gianfranco ^{[1
]}

Unfer, Vittorio ^{[1
]}

Roseff, Scott ^{[2
]}

机构：

[1] AGUNCO, Obstet & Gynecol Ctr, I-00155 Rome, Italy

[2] Palm Beach Ctr Reprod Med, Wellington, FL USA

来源：

FERTILITY AND STERILITY | 2011年 / 95卷 / 08期

关键词：

Myo-inositol; D-chiro-inositol; PCOS; oocyte quality; FSH; SPERM INJECTION CYCLES; IMPROVE OOCYTE QUALITY; REVISED; 2003; CONSENSUS; INSULIN-RESISTANCE; DIAGNOSTIC-CRITERIA; POLYCYSTIC OVARIES; FOLLICULAR-FLUID; RANDOMIZED-TRIAL; MYOINOSITOL; WOMEN;

D O I：

10.1016/j.fertnstert.2011.05.027

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The D-chiro-inositol-to-myo-inositol ratio is regulated by an insulin-dependent epimerase. Enzyme activity varies among tissues, likely owing to the specific needs of the two different molecules. We hypothesize that in the ovaries of polycystic ovary syndrome patients, epimerase activity is enhanced, leading to a local myo-inositol deficiency which in turn is responsible for the poor oocyte quality. (Fertil Steril (R) 2011; 95: 2515-6. (c) 2011 by American Society for Reproductive Medicine.)

引用

页码：2515 / 2516

页数：2

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