Case Report: Use of Plasma Exchange Followed by Convalescent Plasma Therapy in a Critically Ill Patient with Severe Fever and Thrombocytopenia Syndrome-Associated Encephalopathy: Cytokine/Chemokine Concentrations, Viral Loads, and Antibody Responses

被引:14
作者
Choi, Sungim [1 ]
Kim, Min-Chul [1 ,2 ]
Kwon, Ji-Soo [1 ]
Kim, Ji-Yeun [1 ]
Lee, Keun Hwa [3 ]
Kim, Sung-Han [1 ]
机构
[1] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Infect Dis, 88,Olymp Ro 43 Gil, Seoul 05505, South Korea
[2] Chung Ang Univ Hosp, Dept Internal Med, Div Infect Dis, Seoul, South Korea
[3] Jeju Natl Univ, Coll Med, Dept Microbiol & Immunol, Jeju, South Korea
关键词
INFLUENZA; BUNYAVIRUS; DISEASE;
D O I
10.4269/ajtmh.17-0766
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
We describe the case of a patient with severe fever with thrombocytopenia syndrome (SFTS) complicated by SFTS-associated encephalopathy who was successfully treated with 4-day plasma exchange followed by two-time convalescent plasma therapy. During plasma exchange, the plasma cytokines interferon-a and inducible protein-10 gradually decreased without change of plasma viral load. However, plasma viral load gradually decreased after convalescent plasma therapy. This case provides important insights for understanding the mechanisms of experimental therapy in severely affected SFTS patients.
引用
收藏
页码:1466 / 1468
页数:3
相关论文
共 16 条
[1]   Immune plasma for the treatment of severe influenza: an open-label, multicentre, phase 2 randomised study [J].
Beigel, John H. ;
Tebas, Pablo ;
Elie-Turenne, Marie-Carmelle ;
Bajwa, Ednan ;
Bell, Todd E. ;
Cairns, Charles B. ;
Shoham, Shmuel ;
Deville, Jaime G. ;
Feucht, Eric ;
Feinberg, Judith ;
Luke, Thomas ;
Raviprakash, Kanakatte ;
Danko, Janine ;
O'Neil, Dorothy ;
Metcalf, Julia A. ;
King, Karen ;
Burgess, Timothy H. ;
Aga, Evgenia ;
Lane, H. Clifford ;
Hughes, Michael D. ;
Davey, Richard T. .
LANCET RESPIRATORY MEDICINE, 2017, 5 (06) :500-511
[2]   Severe fever with thrombocytopenia syndrome bunyavirus-related human encephalitis [J].
Cui, Ning ;
Liu, Rong ;
Lu, Qing-Bin ;
Wang, Li-Yuan ;
Qin, Shu-Li ;
Yang, Zhen-Dong ;
Zhuang, Lu ;
Liu, Kun ;
Li, Hao ;
Zhang, Xiao-Ai ;
Hu, Jian-Gong ;
Wang, Jing-Yu ;
Liu, Wei ;
Cao, Wu-Chun .
JOURNAL OF INFECTION, 2015, 70 (01) :52-59
[3]   Convalescent Plasma Treatment Reduced Mortality in Patients With Severe Pandemic Influenza A (H1N1) 2009 Virus Infection [J].
Hung, Ivan F. N. ;
To, Kelvin K. W. ;
Lee, Cheuk-Kwong ;
Lee, Kar-Lung ;
Chan, Kenny ;
Yan, Wing-Wah ;
Liu, Raymond ;
Watt, Chi-Leung ;
Chan, Wai-Ming ;
Lai, Kang-Yiu ;
Koo, Chi-Kwan ;
Buckley, Tom ;
Chow, Fu-Loi ;
Wong, Kwan-Keung ;
Chan, Hok-Sum ;
Ching, Chi-Keung ;
Tang, Bone S. F. ;
Lau, Candy C. Y. ;
Li, Iris W. S. ;
Liu, Shao-Haei ;
Chan, Kwok-Hung ;
Lin, Che-Kit ;
Yuen, Kwok-Yung .
CLINICAL INFECTIOUS DISEASES, 2011, 52 (04) :447-456
[4]  
Kawashima Hisashi, 2005, J Infect, V51, pE53, DOI 10.1016/j.jinf.2004.08.017
[5]   Successful treatment of rapidly progressing severe fever with thrombocytopenia syndrome with neurological complications using intravenous immunoglobulin and corticosteroid [J].
Kim, Uh Jin ;
Kim, Dong-Min ;
Ahn, Joon Hwan ;
Kang, Seung-Ji ;
Jang, Hee-Chang ;
Park, Kyung-Hwa ;
Jung, Sook In .
ANTIVIRAL THERAPY, 2016, 21 (07) :637-640
[6]   Nosocomial Transmission of Severe Fever With Thrombocytopenia Syndrome in Korea [J].
Kim, Won Young ;
Choi, WooYoung ;
Park, Sun-Whan ;
Wang, Eun Byeol ;
Lee, Won-Ja ;
Jee, Youngmee ;
Lim, Kyoung Soo ;
Lee, Hyun-Jung ;
Kim, Sun-Mi ;
Lee, Sang-Oh ;
Choi, Sang-Ho ;
Kim, Yang Soo ;
Woo, Jun Hee ;
Kim, Sung-Han .
CLINICAL INFECTIOUS DISEASES, 2015, 60 (11) :1681-1683
[7]   Evaluation of Plasma Exchange and Continuous Veno-Venous Hemofiltration for the Treatment of Severe Avian Influenza A (H7N9): A Cohort Study [J].
Liu, Xiaoli ;
Zhang, Yimin ;
Xu, Xiaowei ;
Du, Weibo ;
Su, Kunkai ;
Zhu, Chunxia ;
Chen, Yuemei ;
Lei, Shuiying ;
Zheng, Shufa ;
Jiang, Jianwen ;
Yang, Shigui ;
Guo, Jing ;
Shao, Li ;
Yang, Qian ;
Chen, Jiajia ;
Li, Lanjuan .
THERAPEUTIC APHERESIS AND DIALYSIS, 2015, 19 (02) :178-184
[8]   The Effectiveness of Convalescent Plasma and Hyperimmune Immunoglobulin for the Treatment of Severe Acute Respiratory Infections of Viral Etiology: A Systematic Review and Exploratory Meta-analysis [J].
Mair-Jenkins, John ;
Saavedra-Campos, Maria ;
Baillie, J. Kenneth ;
Cleary, Paul ;
Khaw, Fu-Meng ;
Lim, Wei Shen ;
Makki, Sophia ;
Rooney, Kevin D. ;
Nguyen-Van-Tam, Jonathan S. ;
Beck, Charles R. .
JOURNAL OF INFECTIOUS DISEASES, 2015, 211 (01) :80-90
[9]   Effect of Early Plasma Exchange on Survival in Patients with Severe Fever with Thrombocytopenia Syndrome: A Multicenter Study [J].
Oh, Won Sup ;
Yoo, Jeong Rae ;
Kwon, Ki Tae ;
Kim, Hye In ;
Lee, Su Jin ;
Jun, Jae-Bum ;
Ryu, Seong Yeol ;
Kim, Hyun Ah ;
Hur, Jian ;
Wi, Yu Mi ;
Lim, Min Hee ;
Heo, Sang Taek .
YONSEI MEDICAL JOURNAL, 2017, 58 (04) :867-871
[10]   Use of Plasma Therapy for Severe Fever with Thrombocytopenia Syndrome Encephalopathy [J].
Park, Se Yoon ;
Choi, Woo Young ;
Chong, Yong Pil ;
Park, Sun-Whan ;
Wang, Eun Byeol ;
Lee, Won-Ja ;
Jee, Youngmee ;
Kwon, Seog-Woon ;
Kim, Sung-Han .
EMERGING INFECTIOUS DISEASES, 2016, 22 (07) :1306-1308