The diagnostic value of serum YKL-40 in endometrial cancer: a meta-analysis

被引:7
作者
Qin, Rongyan [1 ]
Liao, Ming [1 ]
Qin, Weili [1 ]
Wang, Jiawei [1 ]
Zheng, Fengque [1 ]
Ma, Nana [1 ]
Zhao, Yunxiao [1 ]
Qin, Aiping [1 ]
机构
[1] Guangxi Med Univ, Affiliated Hosp 1, Reprod Med Ctr, Nanning, Peoples R China
关键词
Biomarker; diagnosis; endometrial cancer; meta-analysis; YKL-40; WOMEN; 45; YEARS; PROGNOSIS; HE-4; EXPRESSION; YOUNGER; MARKER; CA125; GRADE; AGE;
D O I
10.1080/1354750X.2021.2024603
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Background Serum YKL-40 is a promising non-invasive biomarker for the early diagnosis of endometrial cancer (EC), but its value is disputed. Objective To investigate the serum YKL-40 in the early diagnostic value of EC. Methods Databases were systematically searched again before April 2021 and 14 studies were finally included in this meta-analysis. Pooled sensitivity, specificity, negative likelihood ratio (NLR), positive likelihood ratio (PLR), diagnostic odds ratio (DOR), and summary receiver operating characteristic (SROC) curve analyses were assessed. This meta-analysis investigated the source of heterogeneity using sensitivity analysis, subgroup analysis, and meta-regression. Results Databases were systematically searched again before April 2021 and 14 studies were finally included in this meta-analysis. First, the SROC curve presented an area under the curve (AUC) of 0.853 (SE = 0.0213) for YKL-40 alone and an AUC of 0.946 (SE = 0.0268) for YKL-40 combined with other biomarkers. Second, diagnostic types might be related to the diagnostic accuracy and is a significant source of heterogeneity (P = 0.035). Conclusion Serum YKL-40 helped diagnose EC, and its combination with other biomarkers was better than itself alone.
引用
收藏
页码:215 / 221
页数:7
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