Selective cyclooxygenase-2 inhibitors: A review of recent chemical scaffolds with promising anti-inflammatory and COX-2 inhibitory activities

Selective cyclooxygenase-2 (COX-2) inhibitors have exhibited notable medicinal importance. In recent years, the discovery of new anti-inflammatory agents as selective COX-2 inhibitors has acquired more attention. This is due to the fact that currently available COX-2 inhibitors are linked with adverse effects. Various new organic scaffolds are being explored as new COX-2 inhibitors. In this review, we have mainly described different chemical scaffolds which have been investigated for COX-2 inhibition and anti-inflammatory activity. In the current review, literature from the last 10 years has been included. It will be helpful for organic and medicinal chemists to scrutinize new agents with minimum side effects.