Rhodium Catalyzed Arylation of Diazo Compounds with Aryl Boronic Acids

被引：35

作者：

Ghorai, Jayanta ^{[1
]}

Anbarasan, Pazhamalai ^{[1
]}

机构：

[1] Indian Inst Technol, Dept Chem, Madras 600036, Tamil Nadu, India

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2015年 / 80卷 / 07期

关键词：

C-H BONDS; ASYMMETRIC-SYNTHESIS; ALPHA-ARYLATION; ESTERS; FUNCTIONALIZATION; DIAZOESTERS; ALKYLATION;

D O I：

10.1021/jo502922r

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A genetal and efficient synthesis of diary-lacetate, a diarylmethine derivative, was accomplished through rhodium catalyzed direct arylation of diazo compounds with arylboronic acids. The reaction tolerates various boronic acid derivatives and, functional groups. Notably, chemoselective arylation of diazo compounds over other electrophiles were demonstrated. The efficacy of the developed methodology is shown by the expeditious synthesis of the core structure of diclofensine.

引用

页码：3455 / 3461

页数：7

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