Synthesis of thiophosphoramidates in water: Click chemistry for phosphates

被引：8
|
作者：
Trmcic, Milena [1 ]
Hodgson, David R. W. [1 ]
机构：
[1] Univ Durham, Dept Chem, Sci Labs, Durham DH1 3LE, England
来源：
CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 21期
关键词：
5'-AMINO-5'-DEOXYGUANOSINE-5'-N-PHOSPHORAMIDATE;
D O I：
10.1039/c1cc11586c
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An aqueous method for the preparation of N,S-dialkyl thiophosphoramidates is reported. Thiophosphorylation of alkylamines was performed using SPCl3 in aqueous reaction media, and the resulting thiophosphoramidate-S-anions were S-alkylated with soft electrophiles. Ranges of amines and electrophiles were explored.
引用
收藏
页码：6156 / 6158
页数：3
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