Synthesis of thiophosphoramidates in water: Click chemistry for phosphates

被引：8

作者：

Trmcic, Milena ^{[1
]}

Hodgson, David R. W. ^{[1
]}

机构：

[1] Univ Durham, Dept Chem, Sci Labs, Durham DH1 3LE, England

来源：

CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 21期

关键词：

5'-AMINO-5'-DEOXYGUANOSINE-5'-N-PHOSPHORAMIDATE;

D O I：

10.1039/c1cc11586c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An aqueous method for the preparation of N,S-dialkyl thiophosphoramidates is reported. Thiophosphorylation of alkylamines was performed using SPCl3 in aqueous reaction media, and the resulting thiophosphoramidate-S-anions were S-alkylated with soft electrophiles. Ranges of amines and electrophiles were explored.

引用

页码：6156 / 6158

页数：3

共 50 条

[31] Expedient Synthesis of SMAMPs via Click Chemistry
Fu, Tsung-hao
Li, Yan
Thaker, Hitesh D.
Scott, Richard W.
Tew, Gregory N.
ACS MEDICINAL CHEMISTRY LETTERS, 2013, 4 (09): : 841 - 845
[32] Synthesis of new substituted lactones by "click" chemistry
Riva, Raphael
Chafaqi, Laila
Jerome, Robert
Lecomte, Philippe
ARKIVOC, 2007, : 292 - 306
[33] Convergent Synthesis of Glycodendropeptides by Click Chemistry Approaches
Kowalczyk, Wioleta
Mascaraque, Ainhoa
Sanchez-Navarro, Macarena
Rojo, Javier
Andreu, David
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2012, 2012 (24) : 4565 - 4573
[34] CLICK CHEMISTRY TOWARD THE SYNTHESIS OF ANTICANCER AGENTS
Pal, Ashutosh
Banik, Bimal Krishna
HETEROCYCLES, 2022, 104 (02) : 229 - 266
[35] Synthesis of fluorescent macrocycles and polymers by click chemistry
Levine, Mindy
Cook, Nicole
Potvin, Joshua
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2012, 244
[36] Accelerated SuFEx Click Chemistry For Modular Synthesis**
Smedley, Christopher J.
Homer, Joshua A.
Gialelis, Timothy L.
Barrow, Andrew S.
Koelln, Rebecca A.
Moses, John E.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2022, 61 (04)
[37] Synthesis of nicotine analogs using click chemistry
Elliot, Katelyn
Bergosh, Robert G.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2013, 245
[38] Catalyst: Click chemistry: A catalyst for the democratization of synthesis
Moorhouse, Adam D.
Homer, Joshua A.
Moses, John E.
CHEM, 2024, 10 (09): : 2615 - 2619
[39] One pot synthesis of nucleoside 5′-thiophosphoramidates
Miao, ZW
Fu, H
Han, B
Zhao, YF
SYNTHETIC COMMUNICATIONS, 2002, 32 (07) : 1069 - 1076
[40] Application of click-click chemistry to the synthesis of new multivalent RGD conjugates
Galibert, Mathieu
Sancey, Lucie
Renaudet, Olivier
Coll, Jean-Luc
Dumy, Pascal
Boturyn, Didier
ORGANIC & BIOMOLECULAR CHEMISTRY, 2010, 8 (22) : 5133 - 5138

← 1 2 3 4 5 →