Thyroid cancer risk in Belarus among children and adolescents exposed to radioiodine after the Chornobyl accident

被引：143
作者：
Zablotska, L. B. [1 ]
Ron, E. [2 ]
Rozhko, A. V. [3 ]
Hatch, M. [2 ]
Polyanskaya, O. N. [3 ]
Brenner, A. V. [2 ]
Lubin, J. [2 ]
Romanov, G. N. [3 ]
McConnell, R. J. [4 ]
O'Kane, P. [5 ]
Evseenko, V. V. [3 ]
Drozdovitch, V. V. [2 ]
Luckyanov, N. [2 ]
Minenko, V. F. [6 ]
Bouville, A. [2 ]
Masyakin, V. B. [3 ]
机构：
[1] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94118 USA
[2] NCI, Div Canc Epidemiol & Genet, NIH, DHHS, Bethesda, MD 20892 USA
[3] Republican Res Ctr Radiat Med & Human Ecol, Gomel 246040, BELARUS
[4] Columbia Univ, Thyroid Ctr, New York, NY 10032 USA
[5] Thomas Jefferson Univ Hosp, Dept Radiol, Philadelphia, PA 19107 USA
[6] Belarusian Med Acad Postgrad Educ, Minsk 220714, BELARUS
来源：
BRITISH JOURNAL OF CANCER | 2011年 / 104卷 / 01期
关键词：
thyroid neoplasms; iodine radioisotopes; Chernobyl nuclear accident; risk; iodine deficiency; IODINE DEFICIENCY; BRYANSK OBLAST; RADIATION; DISEASES; COHORT; NUTRITION; RUSSIA; AREAS; I-131;
D O I：
10.1038/sj.bjc.6605967
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
BACKGROUND: Previous studies showed an increased risk of thyroid cancer among children and adolescents exposed to radioactive iodines released after the Chornobyl (Chernobyl) accident, but the effects of screening, iodine deficiency, age at exposure and other factors on the dose-response are poorly understood. METHODS: We screened 11 970 individuals in Belarus aged 18 years or younger at the time of the accident who had estimated I-131 thyroid doses based on individual thyroid activity measurements and dosimetric data from questionnaires. The excess odds ratio per gray (EOR/Gy) was modelled using linear and linear-exponential functions. RESULTS: For thyroid doses <5 Gy, the dose-response was linear (n = 85; EOR/Gy = 2.15, 95% confidence interval: 0.81-5.47), but at higher doses the excess risk fell. The EOR/Gy was significantly increased among those with prior or screening-detected diffuse goiter, and larger for men than women, and for persons exposed before age 5 than those exposed between 5 and 18 years, although not statistically significant. A somewhat higher EOR/Gy was estimated for validated pre-screening cases. CONCLUSION: 10-15 years after the Chornobyl accident, thyroid cancer risk was significantly increased among individuals exposed to fallout as children or adolescents, but the risk appeared to be lower than in other Chornobyl studies and studies of childhood external irradiation. British Journal of Cancer (2011) 104, 181-187. doi: 10.1038/sj.bjc.6605967 www.bjcancer.com Published online 23 November 2010 (C) 2011 Cancer Research UK
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页码：181 / 187
页数：7
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