Haematological and biochemical reference intervals for infants and children in Gabon

被引:14
|
作者
Humberg, Alexander [1 ,2 ]
Kammer, Judith [1 ,2 ]
Mordmueller, Benjamin [1 ,2 ]
Kremsner, Peter G. [1 ,2 ]
Lell, Bertrand [1 ,2 ]
机构
[1] Univ Tubingen, Inst Trop Med, Tubingen, Germany
[2] Albert Schweitzer Hosp, Med Res Unit, Lambarene, Gabon
关键词
haematology; reference intervals; normal values; infants; children; Africa; IRON-DEFICIENCY; PLATELET COUNT; AFRICAN IMMIGRANTS; REFERENCE VALUES; BLACK-AMERICANS; CELL VOLUME; INDEXES; AGE; EOSINOPHILIA; NEUTROPENIA;
D O I
10.1111/j.1365-3156.2010.02705.x
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
OBJECTIVES To establish reference intervals for major haematological and biochemical parameters in Gabonese infants and children. METHODS The reference sample population consisted of 226 healthy infants (4-9 weeks of age) and 185 healthy children (18-60 months of age). Basic red cell parameters as well as total and differential white blood cell counts were performed. Clinical chemistry parameters consisted of glutamate pyruvic transaminase and creatinine, and total bilirubin was measured in children. Statistical analysis was based on the guidelines of the Clinical and Laboratory Standards Institute. Nonparametric methods were used to determine 95% reference limits and their 90% confidence intervals. RESULTS Compared to European populations, values for several red cell parameters (haemoglobin, haematocrit, red blood cell count, mean corpuscular volume) were lower and platelet counts were higher. Eosinophils were higher in the older age group, most likely caused by intestinal helminths. CONCLUSIONS The study confirms the importance of establishing reference limits for local populations. The reference ranges could be used as a benchmark for similar populations in Central Africa.
引用
收藏
页码:343 / 348
页数:6
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