Human β-Defensin 2 and Its Postulated Role in Modulation of the Immune Response

被引：52
作者：
Cieslik, Martyna [1 ]
Baginska, Natalia [1 ]
Gorski, Andrzej [1 ,2 ,3 ]
Jonczyk-Matysiak, Ewa [1 ]
机构：
[1] Polish Acad Sci, Hirszfeld Inst Immunol & Expt Therapy, Bacteriophage Lab, PL-53114 Wroclaw, Poland
[2] Polish Acad Sci, Hirszfeld Inst Immunol & Expt Therapy, Phage Therapy Unit, PL-53114 Wroclaw, Poland
[3] Med Univ Warsaw, Infant Jesus Hosp, PL-02006 Warsaw, Poland
来源：
CELLS | 2021年 / 10卷 / 11期
关键词：
human beta-defensin; hBD-2; small antimicrobial peptides; innate immunity; epithelium; HUMAN BETA-DEFENSIN-2 EXPRESSION; NF-KAPPA-B; HELICOBACTER-PYLORI; ANTIMICROBIAL PEPTIDES; EPITHELIAL-CELLS; GENE-EXPRESSION; PSEUDOMONAS-AERUGINOSA; INDUCIBLE EXPRESSION; SIGNALING PATHWAYS; INNATE IMMUNITY;
D O I：
10.3390/cells10112991
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Studies described so far suggest that human beta-defensin 2 is an important protein of innate immune response which provides protection for the human organism against invading pathogens of bacterial, viral, fungal, as well as parasitical origin. Its pivotal role in enhancing immunity was proved in infants. It may also be considered a marker of inflammation. Its therapeutic administration has been suggested for maintenance of the balance of systemic homeostasis based on the appropriate composition of the microbiota. It has been suggested that it may be an important therapeutic tool for modulating the response of the immune system in many inflammatory diseases, offering new treatment modalities. For this reason, its properties and role in the human body discussed in this review should be studied in more detail.
引用
收藏
页数：18
相关论文
共 137 条
[1]   THE IMMUNE-SYSTEM AND THE NERVOUS-SYSTEM [J].
AARLI, JA .
JOURNAL OF NEUROLOGY, 1983, 229 (03) :137-154
[2]   Human beta-defensins 2 and 4 are dysregulated in patients with coronavirus disease 19 [J].
Al-Bayatee, Noor T. ;
Ad'hiah, Ali H. .
MICROBIAL PATHOGENESIS, 2021, 160
[3]   Dysregulation of Human β-Defensin-2 Protein in Inflammatory Bowel Disease [J].
Aldhous, Marian C. ;
Noble, Colin L. ;
Satsangi, Jack .
PLOS ONE, 2009, 4 (07)
[4]   Inducible expression of beta defensins by human respiratory epithelial cells exposed to Aspergillus fumigatus organisms [J].
Alekseeva, Ludmila ;
Huet, Dominique ;
Femenia, Francoise ;
Mouyna, Isabelle ;
Abdelouahab, Mahdia ;
Cagna, Adrien ;
Guerrier, Daniel ;
Tichanne-Seltzer, Virginie ;
Baeza-Squiban, Armelle ;
Chermette, Rene ;
Latge, Jean-Paul ;
Berkova, Nadia .
BMC MICROBIOLOGY, 2009, 9
[5]   The role of bacterial skin infections in atopic dermatitis: expert statement and review from the International Eczema Council Skin Infection Group [J].
Alexander, H. ;
Paller, A. S. ;
Traidl-Hoffmann, C. ;
Beck, L. A. ;
De Benedetto, A. ;
Dhar, S. ;
Girolomoni, G. ;
Irvine, A. D. ;
Spuls, P. ;
Su, J. ;
Thyssen, J. P. ;
Vestergaard, C. ;
Werfel, T. ;
Wollenberg, A. ;
Deleuran, M. ;
Flohr, C. .
BRITISH JOURNAL OF DERMATOLOGY, 2020, 182 (06) :1331-1342
[6]   The Vaginal Microenvironment: The Physiologic Role of Lactobacilli [J].
Amabebe, Emmanuel ;
Anumba, Dilly O. C. .
FRONTIERS IN MEDICINE, 2018, 5
[7]  
[Anonymous], 2012, FOOD NUTR SCI
[8]   Toll-like Receptor Signaling Activation by Entamoeba histolytica Induces Beta Defensin 2 in Human Colonic Epithelial Cells: Its Possible Role as an Element of the Innate Immune Response [J].
Ayala-Sumuano, Jorge-Tonatiuh ;
Tellez-Lopez, Victor M. ;
del Carmen Dominguez-Robles, M. ;
Shibayama-Salas, Mineko ;
Meza, Isaura .
PLOS NEGLECTED TROPICAL DISEASES, 2013, 7 (02)
[9]   Modulation of host antimicrobial peptide (β-defensins 1 and 2) expression during gastritis [J].
Bajaj-Elliott, M ;
Fedeli, P ;
Smith, GV ;
Domizio, P ;
Maher, L ;
Ali, RS ;
Quinn, AG ;
Farthing, MJG .
GUT, 2002, 51 (03) :356-361
[10]   Human β-defensin 2 is a salt-sensitive peptide antibiotic expressed in human lung [J].
Bals, R ;
Wang, XR ;
Wu, ZR ;
Freeman, T ;
Bafna, V ;
Zasloff, M ;
Wilson, JM .
JOURNAL OF CLINICAL INVESTIGATION, 1998, 102 (05) :874-880
12345678910