Self-assembling GO/modified HEC hybrid stabilized pickering emulsions and template polymerization for biomedical hydrogels

被引:34
作者
Wang, Xiangdong [1 ]
Yu, Kexin [1 ]
An, Ran [1 ]
Han, Linglin [1 ]
Zhang, Yulin [1 ]
Shi, Lingying [1 ]
Ran, Rong [1 ]
机构
[1] Sichuan Univ, Coll Polymer Sci & Engn, Chengdu 610065, Sichuan, Peoples R China
基金
中国国家自然科学基金;
关键词
Graphene oxide; HEC; Pickering emulsion; Hydrogel; Biomedical material; GRAPHENE-OXIDE; HYDROXYETHYL CELLULOSE; COMPOSITE HYDROGEL; INVERSION; CAPSULES; RECOVERY; DELIVERY; BEHAVIOR; STATE;
D O I
10.1016/j.carbpol.2018.12.034
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
Graphene oxide(GO), as an amphiphilic and biocompatible material, is often used to prepare Pickering emulsion. However, the preparation of stable Pickering emulsion by a low concentration of GO is very challenging. In this research, we prepared the hydrophobic modified hydroxyethyl cellulose (mHEC) which contained quaternary ammonium group and GO which the water contact angle was 84 degrees-86 degrees. A stable, low cost, and biocompatible Pickering emulsion was fabricated by a low concentration of GO and different contents of mHEC. The effects of mHEC concentration, electrolyte concentration, pH, and oil/water ratio on the stability of Pickering emulsion were investigated. What's more, we prepared the biomedical macroporous polyacrylamide hydrogel by the GO/mHEC composite stabilized emulsion template for drug controlled-release. The composite hydrogel by Pickering emulsion template is a potential drug controlled-release delivery platforms. Furthermore, our strategy is extremely versatile, as Pickering particles, polymer and the monomer of hydrogel can all be varied.
引用
收藏
页码:694 / 703
页数:10
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