Long-term cost-effectiveness of clopidogrel in patients with acute coronary syndrome without ST-segment elevation in Germany

被引：8

作者：

Brueggenjuergen, B. ^{[1
,2
]}

Lindgren, P. ^{[3
]}

Ehlken, B. ^{[4
]}

Rupprecht, H. -J. ^{[5
]}

Willich, S. N. ^{[1
]}

机构：

[1] Charite Univ Med Berlin, Inst Social Med Epidemiol & Hlth Econ, D-10098 Berlin, Germany

[2] Alpha Care Management & Res Hlth Care, Celle, Germany

[3] Stockholm Hlth Econ, Stockholm, Sweden

[4] Med Econ Res Grp MERG, Munich, Germany

[5] GPR Klinikum Russelsheim, Med Klin 2, D-65428 Russelsheim, Germany

来源：

EUROPEAN JOURNAL OF HEALTH ECONOMICS | 2007年 / 8卷 / 01期

关键词：

acute coronary syndrome; clopidogrel; cost-effectiveness; long-term impact; Markov model; Germany;

D O I：

10.1007/s10198-006-0006-5

中图分类号：

F [经济];

学科分类号：

02 ;

摘要：

Patients with acute coronary syndrome without ST-segment elevation receiving clopidogrel in addition to acetylsalicylic acid (ASA) showed a 20% risk reduction in comparison to patients receiving ASA monotherapy (CURE trial). Economic models for assessing the impact on costs exist for several countries but not for Germany on a long-term basis. The objective of this model adaptation is to assess the long-term economic impact of clopidogrel taken in addition to ASA in Germany. A Markov model with six states [at risk, first year with stroke, following years with stroke, first year with new myocardial infarction (MI), following years with Ml, and death] was adapted for Germany. Model outcome was life-years saved. Effects of 1-year treatment were calculated based on the CURE trial. Resource use for the different health states was based on published data, which included costs for drugs, outpatient care, hospitalization, rehabilitation and nursing. Risk data for MI and stroke were based on Swedish data and validated for the German adaptation. The model calculates lifetime costs and survival length. Costs were estimated from the payers' perspective. A series of one-way sensitivity analyses was conducted (follow-up costs, discount rates). The Markov analysis predicts a survival of sic8.89 years in the placebo treatment group and 9.02 years in the clopidogrel treatment group. The cumulated costs were sic8,548 and sic8,953, respectively. The incremental cost-effectiveness ratio (ICER) was sic3,113 for each life-year saved. The model was robust regarding variations in key parameters in the sensitivity analysis, resulting in a range of ICER from sic1,338 to sic9,322. Our results are in line with the results for other healthcare systems. Adding clopidogrel to ASA for patients with acute coronary syndrome without ST-segment elevation generated an additional life-year saved at a comparably low value of sic3,113. One-year treatment with clopidogrel is a cost-effective treatment option in patients with acute coronary syndrome from the perspective of a third-party payer in Germany.

引用

页码：51 / 57

页数：7