A mouse model of weight gain after nicotine withdrawal

被引：5

作者：

Takeda, Katsushi ^{[1
]}

Aotani, Daisuke ^{[1
]}

Kuga, Yusuke ^{[1
]}

Jinno, Tomoki ^{[2
]}

Guo, Tingting ^{[1
]}

Ogawa, Kento ^{[1
]}

Shimizu, Yuki ^{[1
]}

Hattori, Rei ^{[1
]}

Yagi, Takashi ^{[1
]}

Koyama, Hiroyuki ^{[1
]}

Matsumura, Shigenobu ^{[2
,3
]}

Kataoka, Hiromi ^{[1
]}

Tanaka, Tomohiro ^{[1
]}

机构：

[1] Nagoya City Univ, Grad Sch Med Sci, Dept Gastroenterol & Metab, Mizuho Ku, 1 Kawasumi,Mizuho Cho, Nagoya, Aichi 4678601, Japan

[2] Kyoto Univ, Grad Sch Agr, Div Food Sci & Biotechnol, Sakyo Ku, Kitashirakawa Oiwake Cho, Kyoto 6068502, Japan

[3] Osaka Prefecture Univ, Grad Sch Comprehens Rehabil, 3-7-30 Habikino, Habikino, Osaka 5838555, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2022年 / 588卷

关键词：

Nicotine; Smoking cessation; Obesity; Pair-feeding; Neuropeptide; Glucagon-like peptide-1; SMOKING-CESSATION; BODY-WEIGHT; ACTIVATION; EXPRESSION; DISEASE;

D O I：

10.1016/j.bbrc.2021.12.064

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Smoking cessation increases body weight. The underlying mechanisms, however, have not been fully understood. We here report an establishment of a mouse model that exhibits an augmented body weight gain after nicotine withdrawal. High fat diet-fed mice were infused with nicotine for two weeks, and then with vehicle for another two weeks using osmotic minipumps. Body weight increased immediately after nicotine cessation and was significantly higher than that of mice continued on nicotine. Mice switched to vehicle consumed more food than nicotine-continued mice during the first week of cessation, while oxygen consumption was comparable. Elevated expression of orexigenic agouti-related peptide was observed in the hypothalamic appetite center. Pair-feeding experiment revealed that the accelerated weight gain after nicotine withdrawal is explained by enhanced energy intake. As a showcase of an efficacy of pharmacologic intervention, exendin-4 was administered and showed a potent suppression of energy intake and weight gain in mice withdrawn from nicotine. Our current model provides a unique platform for the investigation of the changes of energy regulation after smoking cessation. (c) 2021 Elsevier Inc. All rights reserved.

引用

页码：140 / 146

页数：7

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