Clinical accuracy of anti-tissue transglutaminase as screening test for celiac disease under 2 years

被引：12

作者：

Panetta, Fabio ^{[1
,2
]}

Torre, Giuliano ^{[1
]}

Colistro, Franco ^{[3
]}

Ferretti, Francesca ^{[1
]}

Daniele, Antonella ^{[1
]}

Diamanti, Antonella ^{[1
]}

机构：

[1] Bambino Gesu Pediat Hosp, Hepatol Gastroenterol & Nutr Unit, I-00165 Rome, Italy

[2] Univ Hosp G Martino, Messina, Italy

[3] Bambino Gesu Pediat Hosp, Biochem Lab, I-00165 Rome, Italy

来源：

ACTA PAEDIATRICA | 2011年 / 100卷 / 05期

关键词：

Anti-tissue transglutaminase; Celiac disease; Chemiluminescent assay; Children; HUMAN TISSUE TRANSGLUTAMINASE; PEDIATRIC-GASTROENTEROLOGY; FOLLOW-UP; DIAGNOSIS; MULTICENTER; ANTIBODIES; CHILDREN; ANTIGLIADIN; HEPATOLOGY; NUTRITION;

D O I：

10.1111/j.1651-2227.2010.02124.x

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Aim: To investigate, in patients with suspected celiac disease (CD) younger than 2 years, the clinical value of anti-tissue transglutaminase (tTG) in diagnostic work-up of CD. Methods: Between June 2005 and June 2009, 169 patients aged < 2 years, with symptoms suggestive of CD, were submitted to biopsy. CD diagnosis was based on the revised criteria of the European Society for Pediatric Gastroenterology, Hepatology and Nutrition. Results: Of the 169 patients enrolled, 155 were included: 108 of them showed mucosal atrophy and 47 negative histology. Sensitivity and specificity of tTG, at the cut-off of 8 AU/mL, were 0.96 (CI 0.91-0.99) and 0.91 (CI 0.80-0.98), respectively, with likelihood ratio (LR) of 11.31; at the cut-off of 16 AU/mL, they were 0.79 (CI 0.70-0.86) and 1.00, respectively (CI 0.92-1.00), with LR 4.50. Conclusions: In patients younger than 2 years, suspected for CD, tTG is very valuable in selecting for small intestinal biopsy.

引用

页码：728 / 731

页数：4

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