Molecular profile of the unique species of traditional Chinese medicine, Chinese seahorse (Hippocampus kuda Bleeker)

被引：41

作者：

Zhang, N ^{[1
]}

Xu, B ^{[1
]}

Mou, CY ^{[1
]}

Yang, WL ^{[1
]}

Wei, JW ^{[1
]}

Lu, L ^{[1
]}

Zhu, JJ ^{[1
]}

Du, JC ^{[1
]}

Wu, XK ^{[1
]}

Ye, LT ^{[1
]}

Fu, ZY ^{[1
]}

Lu, Y ^{[1
]}

Lin, JH ^{[1
]}

Sun, ZZ ^{[1
]}

Su, J ^{[1
]}

Dong, ML ^{[1
]}

Xu, AL ^{[1
]}

机构：

[1] Zhongshan Univ, Coll Life Sci, Guangzhou Ctr Bioinformat, Dept Biochem,Open Lab Marine Funct Genom State Hi, Guangzhou 510275, Peoples R China

来源：

FEBS LETTERS | 2003年 / 550卷 / 1-3期

基金：

中国国家自然科学基金;

关键词：

Chinese seahorse; expressed sequence tag; Chinese traditional medicine; C-type lectin; innate immune; paternal brooding;

D O I：

10.1016/S0014-5793(03)00855-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A cDNA library of male Chinese seahorse (Hippocampus kuda Bleeker) was constructed to investigate the molecular profile of seahorse as one of the most famous traditional Chinese medicine materials, and to reveal immunological and physiological mechanisms of seahorse as one of the most primitive vertebrates at molecular level. A total of 3372 expressed sequence tags (ESTs) consisting of 1911 unique genes (345 clusters and 1566 singletons) were examined in the present study. Identification of the genes related to immune system, paternal brooding and physiological regulation provides not only valuable insights into the molecular mechanism of immune system in teleost fish but also plausible explanations for pharmacological activities of Chinese seahorse. Furthermore, the occurrence of high prevalent C-type lectins suggested that a lectin-complement pathway might exert a more dominant function in the innate immune system of teleost than mammal. Carbohydrate recognition domain (CRD) without a collagen-like region in the lectins of seahorse was likely an ancient characteristic of lectins similar to invertebrates. (C) 2003 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.

引用

页码：124 / 134

页数：11

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