Virulence and Pathogenicity Properties of Aggregatibacter actinomycetemcomitans

被引：78

作者：

Belibasakis, Georgios N. ^{[1
]}

Maula, Terhi ^{[2
]}

Bao, Kai ^{[1
]}

Lindholm, Mark ^{[3
]}

Bostanci, Nagihan ^{[1
]}

Oscarsson, Jan ^{[3
]}

Ihalin, Riikka ^{[2
]}

Johansson, Anders ^{[3
]}

机构：

[1] Karolinska Inst, Dept Dent Med, Div Oral Dis, S-14104 Huddinge, Sweden

[2] Univ Turku, Dept Biochem, FI-20014 Turku, Finland

[3] Umea Univ, Dept Odontol, S-90187 Umea, Sweden

来源：

PATHOGENS | 2019年 / 8卷 / 04期

基金：

瑞典研究理事会; 芬兰科学院;

关键词：

Aggregatibacter actinomycetemcomitans; leukotoxin; cytolethal distending toxin; lipopolysaccharides; cytokine binding factors; horizontal gene transfer; outer membrane vesicles; biofilm; proteomic; CYTOLETHAL DISTENDING TOXIN; OUTER-MEMBRANE VESICLES; CELL-CYCLE ARREST; HUMAN GINGIVAL FIBROBLASTS; PERIODONTAL-LIGAMENT CELLS; LEUKOTOXIN PROMOTER REGION; ACTINOBACILLUS-ACTINOMYCETEMCOMITANS; NATURAL COMPETENCE; ESCHERICHIA-COLI; JP2; CLONE;

D O I：

10.3390/pathogens8040222

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Aggregatibacter actinomycetemcomitans is a periodontal pathogen colonizing the oral cavity of a large proportion of the human population. It is equipped with several potent virulence factors that can cause cell death and induce or evade inflammation. Because of the large genetic diversity within the species, both harmless and highly virulent genotypes of the bacterium have emerged. The oral condition and age, as well as the geographic origin of the individual, influence the risk to be colonized by a virulent genotype of the bacterium. In the present review, the virulence and pathogenicity properties of A. actinomycetemcomitans will be addressed.

引用

页数：23

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